Relationship of SOD-1 Activity in Metabolic Syndrome and/or Frailty in Elderly Individuals.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2024-09-23 DOI:10.3390/metabo14090514

Sylwia Dzięgielewska-Gęsiak, Ewa Wysocka, Edyta Fatyga, Małgorzata Muc-Wierzgoń

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引用次数: 0

Abstract

Introduction: Although aging is a natural phenomenon, in recent years it has accelerated. One key factor implicated in the aging process is oxidative stress. Oxidative stress also plays a role in frailty (frail) and metabolic syndrome (MetS).

Methods: A total of 66 elderly persons (65 years old and older) with no acute or severe chronic disorders were assessed for waist circumference (WC), arterial blood pressure, glycemia, glycated hemoglobin (HbA1c), plasma lipids, and activity of erythrocyte superoxide dismutase (SOD-1). Patients were classified as NonMetS-Nonfrail (n = 19), NonMetS-frail (n = 20), MetS-Nonfrail (n = 17), or MetS-frail (n = 10).

Results: There were no significant differences in superoxide dismutase activity among investigated elderly groups. However, the data suggest that MetS individuals, both frail and nonfrail, have higher risk factors for cardiovascular disease compared to NonMetS individuals. The correlations analyses of SOD-1 and other metabolic indices suggest that SOD-1 levels may be influenced by age, total cholesterol, HDL cholesterol, and fasting glucose levels in certain groups of seniors.

Conclusions: Aging is associated with decreased antioxidant enzyme SOD-1 activity with glucose alteration in frailty syndrome as well as with lipids disturbances in metabolic syndrome. These factors provide a nuanced view of how frailty and metabolic syndrome interact with various health parameters, informing both clinical practice and future research directions.

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SOD-1 活性与代谢综合征和/或老年人虚弱的关系

导言虽然衰老是一种自然现象，但近年来衰老的速度却在加快。与衰老过程有关的一个关键因素是氧化应激。氧化应激在虚弱（frail）和代谢综合征（MetS）中也扮演着重要角色：对 66 名无急性或严重慢性疾病的老年人（65 岁及以上）进行了腰围（WC）、动脉血压、血糖、糖化血红蛋白（HbA1c）、血浆脂质和红细胞超氧化物歧化酶（SOD-1）活性的评估。患者被分为非 MetS-Nonfrail（n = 19）、非 MetS-frail（n = 20）、MetS-Nonfrail（n = 17）或 MetS-frail（n = 10）：结果：在接受调查的老年人组中，超氧化物歧化酶活性没有明显差异。然而，数据表明，与非 MetS 群体相比，MetS 群体（包括体弱和非体弱群体）具有更高的心血管疾病风险因素。SOD-1与其他代谢指标的相关性分析表明，在某些老年人群体中，SOD-1水平可能会受到年龄、总胆固醇、高密度脂蛋白胆固醇和空腹血糖水平的影响：结论：衰老与抗氧化酶 SOD-1 活性的降低、虚弱综合征中葡萄糖的改变以及代谢综合征中血脂紊乱有关。这些因素从细微处说明了虚弱和代谢综合征如何与各种健康参数相互作用，为临床实践和未来研究方向提供了参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.