The crossroad between tumor and endothelial cells.

IF 3.2 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Clinical and Experimental Medicine Pub Date : 2024-09-26 DOI:10.1007/s10238-024-01490-1

Domenico Ribatti

引用次数: 0

Abstract

Endothelial cells are critical in tumor development, and the specific targeting of endothelial cells offers a potent means to effectively impede angiogenesis and suppress the growth of tumors. Tumor endothelial cells are responsible for the loss of anticancer immunity, the so-called endothelial anergy, i.e., the unresponsiveness of tumor endothelial cells to pro-inflammatory stimulation, not allowing adhesion of immune cells to the endothelium. Endothelial cells downregulate antigen presentation and recruitment of immune cells, contributing to immunosuppression. Targeting endothelial cells may assist in improving the immune effect of immune cells in tumor microenvironment.

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肿瘤和内皮细胞之间的十字路口。

内皮细胞在肿瘤发生发展过程中至关重要，特异性靶向内皮细胞是有效阻碍血管生成和抑制肿瘤生长的有力手段。肿瘤内皮细胞是导致抗癌免疫力丧失的原因，即所谓的内皮细胞失活，即肿瘤内皮细胞对促炎性刺激无反应，不允许免疫细胞粘附在内皮上。内皮细胞会下调抗原递呈和免疫细胞的招募，从而导致免疫抑制。靶向内皮细胞可能有助于改善免疫细胞在肿瘤微环境中的免疫效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Medicine 医学-医学：研究与实验

CiteScore

4.80

自引率

2.20%

发文量

159

审稿时长

2.5 months

期刊介绍： Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.