Severe fever with thrombocytopenia syndrome (SFTS) in Thailand: using a one health approach to respond to novel zoonosis and its implications in clinical practice.

IF 3.8 Q2 INFECTIOUS DISEASES
Chalo Sansilapin, Ratanaporn Tangwangvivat, Curtis S Hoffmann, Chanatip Chailek, Paisin Lekcharoen, Nattakarn Thippamom, Sininat Petcharat, Piyanan Taweethavonsawat, Supaporn Wacharapluesadee, Rome Buathong, Takeshi Kurosu, Tomoki Yoshikawa, Masayuki Shimojima, Sopon Iamsirithaworn, Opass Putcharoen
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Abstract

Severe fever with thrombocytopenia syndrome (SFTS), a tick-borne disease caused by Dabie bandavirus (SFTSV) is an emerging infectious disease of substantial concern in East Asia. In 2019, Ongkittikul S et al. reported the first case of SFTS in Thailand. Our report describes a One Health investigation of SFTS zoonosis examining the index case and suspected animal reservoirs using real-time RT-PCR and immunoassays. We add to the report on the first confirmed case of SFTSV infection in a human in Thailand by conducting a limited but informative One Health surveillance study. Dogs and cats tested positive for SFTSV antibody using IgG ELISA. We conclude that domestic dogs and cats might serve as potential reservoirs for SFTSV spread due to their closer proximity to the index case than other non-domestic animals. Notably, we did not detect SFTSV in synanthropic cats or dogs-nor did we detect SFTSV in Rhipicephalus sanguineus ticks-using RT-PCR. We propose that One Health investigations coupling genomic and serologic assays in response to new SFTS cases could play a pivotal role in preventing and managing SFTS among humans and animals in East Asia. As such, we are establishing a collaborative response to SFTS in Thailand through human outbreak investigations that align with principles of One Health, through environmental surveys and animal RT-PCR and immunoassays. Our investigation highlights the importance of coupling RT-PCR with seroprevalence assays as principal elements of One Health surveillance for SFTS in order to shed light on potential animal reservoirs and track emerging zoonosis.

泰国严重发热伴血小板减少综合征 (SFTS):采用统一健康方法应对新型人畜共患病及其对临床实践的影响。
严重发热伴血小板减少综合征(SFTS)是由达比带状疱疹病毒(SFTSV)引起的一种蜱媒疾病,是东亚地区备受关注的一种新发传染病。2019 年,Ongkittikul S 等人报告了泰国首例 SFTS 病例。我们的报告描述了对 SFTS 人畜共患病的 "同一健康 "调查,使用实时 RT-PCR 和免疫测定检查了病例和疑似动物库。我们对泰国首例人感染 SFTSV 确诊病例的报告进行了补充,开展了一项有限但内容丰富的 "同一健康 "监测研究。使用 IgG ELISA 方法检测狗和猫的 SFTSV 抗体呈阳性。我们的结论是,与其他非家养动物相比,家养狗和猫与确诊病例的距离更近,因此可能成为 SFTSV 传播的潜在贮源。值得注意的是,通过 RT-PCR 技术,我们没有在同类的猫或狗体内检测到 SFTSV,也没有在 Rhipicephalus sanguineus 蜱体内检测到 SFTSV。我们建议,针对新的SFTS病例开展基因组学和血清学检测相结合的 "一体健康 "调查,可在预防和管理东亚人类和动物中的SFTS方面发挥关键作用。因此,我们正在泰国开展符合 "一体健康 "原则的人类疫情调查,通过环境调查和动物 RT-PCR 与免疫测定,建立起针对 SFTS 的合作应对措施。我们的调查凸显了将 RT-PCR 与血清流行率检测相结合作为 "一体健康 "监测 SFTS 的主要要素的重要性,从而揭示潜在的动物贮藏库并追踪新出现的人畜共患疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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