Pilot study on the effect of flavonoids on arterial stiffness and oxidative stress in chronic kidney disease.

Anastasia Vagopoulou, Panagiotis Theofilis, Despina Karasavvidou, Nasra Haddad, Dimitris Makridis, Stergios Tzimikas, Rigas Kalaitzidis
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Abstract

Background: Flavonoids, the main class of polyphenols, exhibit antioxidant and antihypertensive properties.

Aim: To prospectively investigate the impact of flavonoids on arterial stiffness in patients with chronic kidney disease (CKD) stages I-IV.

Methods: In this prospective, single-arm study, CKD patients with arterial hypertension and diabetes mellitus were enrolled. Baseline demographic, clinical, and laboratory variables were recorded. Patients received daily treatment with a phenol-rich dietary supplement for 3 months. Blood pressure, arterial stiffness (carotid-femoral pulse wave velocity, central pulse pressure), and oxidative stress markers (protein carbonyls, total phenolic compound, total antioxidant capacity) were measured at baseline and at study end.

Results: Sixteen patients (mean age: 62.5 years, 87.5% male) completed the study. Following intervention, peripheral systolic blood pressure decreased significantly by 14 mmHg (P < 0.001). Carotid-femoral pulse wave velocity decreased from 8.9 m/s (baseline) to 8.2 m/s (study end) (P < 0.001), and central pulse pressure improved from 59 mmHg to 48 mmHg (P = 0.003). Flavonoids also reduced oxidative stress markers including protein carbonyls (P < 0.001), total phenolic compound (P = 0.001), and total antioxidant capacity (P = 0.013).

Conclusion: Flavonoid supplementation in CKD patients shows promise in improving blood pressure, arterial stiffness, and oxidative stress markers.

关于类黄酮对慢性肾脏病患者动脉僵化和氧化应激影响的试点研究。
背景:目的:前瞻性研究类黄酮对慢性肾脏病(CKD)I-IV期患者动脉僵化的影响:在这项前瞻性单臂研究中,招募了患有动脉高血压和糖尿病的慢性肾脏病患者。记录了基线人口统计学、临床和实验室变量。患者每天接受富含苯酚的膳食补充剂治疗,为期 3 个月。在基线和研究结束时测量血压、动脉僵化(颈动脉-股动脉脉搏波速度、中心脉压)和氧化应激指标(蛋白质羰基、总酚化合物、总抗氧化能力):16 名患者(平均年龄 62.5 岁,87.5% 为男性)完成了研究。干预后,外周收缩压明显降低了 14 mmHg(P < 0.001)。颈动脉-股动脉脉搏波速度从 8.9 米/秒(基线)降至 8.2 米/秒(研究结束时)(P < 0.001),中心脉压从 59 毫米汞柱降至 48 毫米汞柱(P = 0.003)。类黄酮还能降低氧化应激指标,包括蛋白质羰基(P < 0.001)、总酚化合物(P = 0.001)和总抗氧化能力(P = 0.013):结论:为慢性肾脏病患者补充类黄酮有望改善血压、动脉僵化和氧化应激指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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