{"title":"Autotaxin concentrations in peritoneal dialysis effluent reflect peritoneal function.","authors":"Keisuke Horikoshi, Norihiko Sakai, Megumi Oshima, Hiroyuki Yamauchi, Megumi Ikeda, Kaho Hayashi, Hiroyoshi Yanagisawa, Fumitaka Yamamori, Sho Kajikawa, Daiki Hayashi, Akihiko Koshino, Keisuke Sako, Takahiro Yuasa, Akira Tamai, Taichiro Minami, Shiori Nakagawa, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Miho Shimizu, Satoshi Oota, Yoichi Ishida, Takashi Wada, Yasunori Iwata","doi":"10.1111/1744-9987.14211","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Peritoneal equilibration test (PET) has been used to monitor peritoneal function. A more convenient marker would be useful in clinical situations including home medical care. Autotaxin is known to leak into the interstitium as vascular permeability increases during the progression of tissue fibrosis. Therefore, we hypothesized that autotaxin concentrations in peritoneal dialysis (PD) effluent might reflect peritoneal function.</p><p><strong>Methods: </strong>This study enrolled 45 patients undergoing PD from 2016 to 2021. Autotaxin concentrations measured in PD effluent were evaluated for their associations with markers obtained from PET.</p><p><strong>Results: </strong>Mean age was 69 years, and 33 patients were men. Univariate and multivariate analyses revealed that autotaxin concentrations are associated with dialysate/plasma creatinine ratio, end/start dialysate glucose ratio, and the dip in the dialysate sodium concentration, a marker of ultrafiltration capacity, at baseline (all p < 0.05).</p><p><strong>Conclusions: </strong>Autotaxin concentrations in PD effluent might be an adjunct marker that reflects peritoneal function.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/1744-9987.14211","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Peritoneal equilibration test (PET) has been used to monitor peritoneal function. A more convenient marker would be useful in clinical situations including home medical care. Autotaxin is known to leak into the interstitium as vascular permeability increases during the progression of tissue fibrosis. Therefore, we hypothesized that autotaxin concentrations in peritoneal dialysis (PD) effluent might reflect peritoneal function.
Methods: This study enrolled 45 patients undergoing PD from 2016 to 2021. Autotaxin concentrations measured in PD effluent were evaluated for their associations with markers obtained from PET.
Results: Mean age was 69 years, and 33 patients were men. Univariate and multivariate analyses revealed that autotaxin concentrations are associated with dialysate/plasma creatinine ratio, end/start dialysate glucose ratio, and the dip in the dialysate sodium concentration, a marker of ultrafiltration capacity, at baseline (all p < 0.05).
Conclusions: Autotaxin concentrations in PD effluent might be an adjunct marker that reflects peritoneal function.
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