[Neoadjuvant Therapy for Resectable or Borderline Resectable Pancreatic Cancer].

Sang Hoon Lee
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Abstract

Surgical resection of a primary tumor is the only effective curative treatment for patients with localized pancreatic cancer without a distant metastasis. Nevertheless, most patients eventually develop postoperative recurrence caused by micrometastases. The risk increases if a complete resection is not achieved. Three surgical stages have emerged for a preoperative assessment based on resectability: resectable, borderline resectable, and unresectable. Although controversial, considerable research has focused on the role of neoadjuvant therapy in all forms of potentially resectable pancreatic cancer. While upfront surgery with adjuvant chemotherapy remains the standard of care for patients with resectable pancreatic cancer, there is growing evidence that neoadjuvant chemotherapy improves overall survival without increasing the resection rate in patients with borderline resectable pancreatic cancer. This review describes the current treatment strategies for resectable and borderline resectable pancreatic cancer and summarizes the results of the latest clinical trials.

[可切除或边缘可切除胰腺癌的新辅助治疗]。
对于没有远处转移的局部胰腺癌患者来说,手术切除原发肿瘤是唯一有效的根治性治疗方法。然而,大多数患者最终会因微小转移而导致术后复发。如果不能实现完全切除,风险就会增加。根据可切除性,术前评估分为三个手术阶段:可切除、边缘可切除和不可切除。尽管存在争议,但相当多的研究都集中在新辅助治疗在所有形式的潜在可切除胰腺癌中的作用上。虽然前期手术和辅助化疗仍是可切除胰腺癌患者的标准治疗方法,但越来越多的证据表明,新辅助化疗可提高边缘可切除胰腺癌患者的总生存率,而不会增加切除率。本综述介绍了目前针对可切除和边缘可切除胰腺癌的治疗策略,并总结了最新的临床试验结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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