Long Term Users of Benzodiazepine Attending the Department of Medicine in a Tertiary Care Hospital.

Mymensingh medical journal : MMJ Pub Date : 2024-10-01
M R Islam, U K T Sultana, T R Khan, M Sultan-E-Monzur, M M Rahman, M F I Juwel
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Abstract

Although comprehensive epidemiological data related to long term use and abuse of benzodiazepine (BZD) in our country is scarce, undocumented clinical observation suggests that the prevalence is quite high and constitutes a significant public health problem. This cross-sectional study was carried out in the Department of Medicine, Shaheed Ziaur Rahman Medical College hospital, Bogra, from 1st October 2015 to 31st March 2016. The objectives of the study were to evaluate the indication, dosage, duration and untoward effects of use of benzodiazepine for one month or longer among the patients attending the inpatient and outpatient departments of medicine. A total of 100 cases of long term benzodiazepine users aged between 18 to 72 years with mean age of 44.0±15.02 years were taken for the study. Male to female ratio of the cases was 1.08:1.00, 97.0% were Muslims, 96.0% were married; 77.0% were rural dwellers. Fifty four (54.0%) cases were from middle class society and 39.0% were housewives by occupation. The benzodiazepine dosage ranged from <5mg to 10mg equivalent to diazepam, with mean dose of 7.5±1.71 and the duration ranged from 1-60 months. Benzodiazepine tolerance was found in 21.0% and dependence in 18.0%. The common reason for taking was benzodiazepine for long duration was the different anxiety disorders in 63.0% followed sleep disturbance in 33.0%. Common cause of long term continuation reported by the respondents was rapid relief of symptoms (51.0%) and lack of awareness (21.0%). In 56.0% cases, the drugs were prescribed by providers other than registered physicians. Only 23.0% of patients were counseled beforehand regarding the probable hazards of long term use of the drugs and the counseling were provided only by registered physicians. In conclusion, it can be said that, large scale epidemiologic studies are warranted to evaluate the weight of burden of benzodiazepines abuse in our community and the needs for changes in clinical approach.

在一家三甲医院内科就诊的苯并二氮杂卓长期使用者。
虽然我国有关长期使用和滥用苯并二氮杂卓(BZD)的全面流行病学数据很少,但无据可查的临床观察结果表明,苯并二氮杂卓的流行率相当高,并构成了一个重大的公共卫生问题。这项横断面研究于 2015 年 10 月 1 日至 2016 年 3 月 31 日在博格拉沙希德-齐亚乌尔-拉赫曼医学院医院医学系进行。研究的目的是评估住院病人和门诊病人使用苯二氮卓类药物一个月或更长时间的适应症、剂量、持续时间和不良反应。研究共选取了 100 例长期服用苯二氮卓类药物的患者,年龄在 18 至 72 岁之间,平均年龄为(44.0±15.02)岁。男女比例为 1.08:1.00,97.0% 为穆斯林,96.0% 已婚,77.0% 为农村居民。54.0%的病例来自中产阶级社会,39.0%的职业为家庭主妇。苯并二氮杂卓的剂量范围为
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