Applying the SOUND Trial for Omitting Axillary Surgery in Patients With Early Breast Cancer in Bahrain.

IF 1.3 Q4 ONCOLOGY
Ali Hasan Abdulla, Reem Althawadi, Ahmed Zuhair Salman, Tareq Hamed Altaei, Amina Mohamed Mahdi, Hussain Adnan Abdulla
{"title":"Applying the SOUND Trial for Omitting Axillary Surgery in Patients With Early Breast Cancer in Bahrain.","authors":"Ali Hasan Abdulla, Reem Althawadi, Ahmed Zuhair Salman, Tareq Hamed Altaei, Amina Mohamed Mahdi, Hussain Adnan Abdulla","doi":"10.4274/ejbh.galenos.2024.2024-5-11","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The Sentinel Node vs. Observation After Axillary Ultra-Sound (SOUND) trial reported that omission of axillary surgery was not inferior to sentinel lymph node biopsy (SLNB) in those with cT1 breast cancer and negative preoperative axillary ultrasound. The aim of our study was to evaluate the clinical characteristics of early breast cancer patients undergoing breast conserving surgery (BCS) at our institution in order to investigate the exportability of SOUND criteria to our patient population.</p><p><strong>Materials and methods: </strong>We retrospectively reviewed patients with cT1N0 breast cancer undergoing BCS and adjuvant radiotherapy according to the SOUND trial criteria. Comparison was made between the eligible group of our cohort and the SLNB arm of the SOUND trial.</p><p><strong>Results: </strong>The proportion of younger patients was higher in our eligible cohort (37.7% vs. 17.5%, <i>p</i> = 0.002). Postmenopausal patients were more prevalent in the SOUND trial (79.4% vs. 56.6%, <i>p</i> = 0.004). On final pathology, tumours were more likely to be upgraded to T2 in our group (26.4% vs. 4.4%, <i>p</i> = 0.001). Patients in our cohort were more likely to receive adjuvant chemotherapy (37.7% vs. 20.1%, <i>p</i> = 0.002).</p><p><strong>Conclusion: </strong>The clinicopathological differences between our cohort and the SOUND trial population could be attributed to aggressive tumours in Bahrain compared to Western countries. Our study may influence others to investigate the applicability of the SOUND trial in clinical practice. Nevertheless, it is a study that should generate multidisciplinary discussion in the de-escalation of axillary surgery.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of breast health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/ejbh.galenos.2024.2024-5-11","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: The Sentinel Node vs. Observation After Axillary Ultra-Sound (SOUND) trial reported that omission of axillary surgery was not inferior to sentinel lymph node biopsy (SLNB) in those with cT1 breast cancer and negative preoperative axillary ultrasound. The aim of our study was to evaluate the clinical characteristics of early breast cancer patients undergoing breast conserving surgery (BCS) at our institution in order to investigate the exportability of SOUND criteria to our patient population.

Materials and methods: We retrospectively reviewed patients with cT1N0 breast cancer undergoing BCS and adjuvant radiotherapy according to the SOUND trial criteria. Comparison was made between the eligible group of our cohort and the SLNB arm of the SOUND trial.

Results: The proportion of younger patients was higher in our eligible cohort (37.7% vs. 17.5%, p = 0.002). Postmenopausal patients were more prevalent in the SOUND trial (79.4% vs. 56.6%, p = 0.004). On final pathology, tumours were more likely to be upgraded to T2 in our group (26.4% vs. 4.4%, p = 0.001). Patients in our cohort were more likely to receive adjuvant chemotherapy (37.7% vs. 20.1%, p = 0.002).

Conclusion: The clinicopathological differences between our cohort and the SOUND trial population could be attributed to aggressive tumours in Bahrain compared to Western countries. Our study may influence others to investigate the applicability of the SOUND trial in clinical practice. Nevertheless, it is a study that should generate multidisciplinary discussion in the de-escalation of axillary surgery.

在巴林应用 SOUND 试验为早期乳腺癌患者省略腋窝手术。
目的:前哨淋巴结与腋窝超声检查后观察(SOUND)试验报告显示,对于术前腋窝超声检查阴性的cT1乳腺癌患者,省略腋窝手术并不比前哨淋巴结活检(SLNB)效果差。我们的研究旨在评估本院接受保乳手术(BCS)的早期乳腺癌患者的临床特征,以研究 SOUND 标准在本院患者中的适用性:我们根据 SOUND 试验标准对接受 BCS 和辅助放疗的 cT1N0 乳腺癌患者进行了回顾性研究。我们将符合条件的组群与 SOUND 试验的 SLNB 组进行了比较:结果:在我们的合格组群中,年轻患者的比例更高(37.7% 对 17.5%,P = 0.002)。绝经后患者在 SOUND 试验中的比例更高(79.4% 对 56.6%,P = 0.004)。最终病理结果显示,我们组的肿瘤更有可能升级为T2(26.4% 对 4.4%,P = 0.001)。我们组的患者更有可能接受辅助化疗(37.7% vs. 20.1%,p = 0.002):结论:与西方国家相比,巴林的肿瘤具有侵袭性,这可能是我们的队列与 SOUND 试验人群之间存在临床病理学差异的原因。我们的研究可能会影响其他研究人员调查 SOUND 试验在临床实践中的适用性。尽管如此,这项研究仍应在腋窝手术降级方面引发多学科讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
2.60
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信