Toll-like Receptors: Therapeutic Potential in Life Threatening Diseases- Cardiac Disorders.

Sonia Singh
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Abstract

Toll-like receptors (TLRs) belong to the innate immune system. TLRs identify and respond to invading pathogens by recognizing certain molecular patterns associated with the infections. TLRs are crucial for the host's defence against these diseases. TLRs are capable of detecting several endogenous chemicals through the recognition of damage-associated molecular patterns, which are generated in response to various harmful situations. Recent animal studies have shown that TLR signaling has a significant role in the development of serious heart diseases, such as ischemia myocardial damage, myocarditis, and septic cardiomyopathy, where inflammation of the heart muscle is a key factor. This manuscript examines the animal research findings on (1) TLRs, TLR ligands, and the signal transduction system, and (2) the significant involvement of TLR signaling in these crucial cardiac diseases.

Toll 样受体:威胁生命的疾病--心脏疾病的治疗潜力。
Toll 样受体(TLR)属于先天性免疫系统。TLRs 通过识别与感染有关的某些分子模式来识别入侵的病原体并做出反应。TLR 对于宿主抵御这些疾病至关重要。TLRs 能够通过识别在各种有害情况下产生的损伤相关分子模式来检测几种内源性化学物质。最近的动物研究表明,TLR 信号在缺血性心肌损伤、心肌炎和脓毒性心肌病等严重心脏疾病的发病过程中起着重要作用,而心肌发炎是其中的一个关键因素。本手稿探讨了有关以下方面的动物研究成果:(1) TLR、TLR 配体和信号转导系统;(2) TLR 信号在这些重要心脏疾病中的重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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