Exploring the intersection of polygenic risk scores and prenatal alcohol exposure: Unraveling the mental health equation

IF 3 Q2 SUBSTANCE ABUSE
Lazer Gerlikhman, Dipak K. Sarkar
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引用次数: 0

Abstract

Background

Prenatal alcohol exposure poses significant risks to offspring mental health. However, the interplay between genetic predispositions to mental health disorders and prenatal alcohol exposure remains incompletely understood, limiting our ability to develop effective interventions for these conditions.

Methods

Data from the Adolescent Brain and Cognitive Development (ABCD) Study were analyzed to explore associations between polygenic risk scores (PRS) for mental disorders and maternal alcohol consumption during pregnancy. Logistic regression and structural equation modeling were utilized to assess these relationships.

Results

Maternal alcohol consumption after pregnancy awareness was significantly associated with an increased genetic risk for specific mental health disorders, particularly bipolar disorder in offspring. The relationship between maternal alcohol consumption and mental health outcomes was influenced by polygenic risk scores, with both externalizing and internalizing problems being affected.

Conclusions

Our findings highlight the specific interaction between increased genetic risk for bipolar disorder and prenatal alcohol exposure in shaping offspring mental health outcomes. The significant associations we observed underscore the importance of considering both polygenic risk scores and prenatal alcohol exposure when assessing mental health risks in children. These insights emphasize the need for targeted interventions that address both genetic predispositions and environmental exposures to better understand and mitigate the impact on offspring mental health.

Abstract Image

探索多基因风险评分与产前酒精暴露的交叉点:解开心理健康方程式。
背景:产前酒精暴露对后代的心理健康具有重大风险。然而,人们对精神疾病的遗传倾向与产前酒精暴露之间的相互作用仍不甚了解,这限制了我们针对这些疾病制定有效干预措施的能力:方法:分析青少年大脑和认知发展(ABCD)研究的数据,探讨精神障碍的多基因风险评分(PRS)与母亲孕期饮酒量之间的关联。利用逻辑回归和结构方程模型来评估这些关系:结果:母亲怀孕后饮酒与后代罹患特定精神疾病(尤其是躁狂症)的遗传风险增加显著相关。母亲饮酒与精神健康结果之间的关系受到多基因风险评分的影响,外化和内化问题都会受到影响:我们的研究结果凸显了双相情感障碍遗传风险的增加与产前酒精暴露在影响后代心理健康结果方面的相互作用。我们观察到的重要关联强调了在评估儿童心理健康风险时同时考虑多基因风险评分和产前酒精暴露的重要性。这些见解强调,需要针对遗传倾向和环境暴露采取有针对性的干预措施,以更好地了解和减轻对后代心理健康的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
5.40
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