Inhibitory control and working memory using saccadic eye movements in primary glaucoma

IF 1.7 4区 心理学 Q3 PSYCHOLOGY
Priyanka Maniarasu, Neetha I. R. Kuzhuppilly, Vijaya Pai H, Ramesh S. Ve, Srinivasa Varadharajan, Shonraj Ballae Ganeshrao
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引用次数: 0

Abstract

Glaucoma is a progressive optic neuropathic disorder that significantly impacts the activities of daily life (ADLs) of individuals. Emerging studies indicate degenerative changes in cortical and subcortical regions in individuals with glaucoma, which are associated with cognitive processes and oculomotor control. Cognitive processes involving top-down processes such as attention, planning, task management and execution, are crucial for meeting the demands of everyday tasks, and are affected in glaucoma. This study investigated the executive functions, specifically inhibitory control (IC) and working memory (WM), in individuals with glaucoma compared to age-matched controls, using eye movements. This was achieved through four tasks sensitive to executive functions, including antisaccade, memory-guided prosaccade and antisaccade, and the Go-NoGo tasks. Saccadic eye-movement parameters were also assessed in a prosaccade task, considered as a control condition with minimal IC and WM load. The results indicated that glaucoma is associated with changes in both IC and WM. Increased anticipatory saccadic errors might be linked to inhibitory deficiencies during the preparatory stage of the saccadic suppression mechanism. The increased omission errors in the antisaccade task might be due to the lack of regulation of the WM component. Taken together, these findings provide evidence for the involvement of cognitive deficits in individuals with glaucoma.

利用原发性青光眼的眼球回旋运动进行抑制控制和工作记忆。
青光眼是一种渐进性视神经病变,严重影响患者的日常生活。新近的研究表明,青光眼患者的皮质和皮质下区域发生了退行性变化,这与认知过程和眼球运动控制有关。认知过程涉及自上而下的过程,如注意力、计划、任务管理和执行,对于满足日常任务的要求至关重要,而青光眼患者的这些认知过程会受到影响。本研究利用眼球运动,对青光眼患者的执行功能,特别是抑制控制(IC)和工作记忆(WM)进行了调查,并与年龄匹配的对照组进行了比较。这项研究通过四项对执行功能敏感的任务来实现,包括反前移、记忆引导的前移和反前移以及Go-NoGo任务。此外,还在将 IC 和 WM 负荷降至最低的对照条件下,评估了前闪任务中的眼球运动参数。结果表明,青光眼与 IC 和 WM 的变化有关。预视盲动错误的增加可能与盲动抑制机制准备阶段的抑制缺陷有关。反误差任务中遗漏错误的增加可能是由于缺乏对 WM 部分的调节。综上所述,这些发现为青光眼患者的认知障碍提供了证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.60
自引率
17.60%
发文量
197
审稿时长
4-8 weeks
期刊介绍: The journal Attention, Perception, & Psychophysics is an official journal of the Psychonomic Society. It spans all areas of research in sensory processes, perception, attention, and psychophysics. Most articles published are reports of experimental work; the journal also presents theoretical, integrative, and evaluative reviews. Commentary on issues of importance to researchers appears in a special section of the journal. Founded in 1966 as Perception & Psychophysics, the journal assumed its present name in 2009.
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