Priyanka Maniarasu, Neetha I. R. Kuzhuppilly, Vijaya Pai H, Ramesh S. Ve, Srinivasa Varadharajan, Shonraj Ballae Ganeshrao
{"title":"Inhibitory control and working memory using saccadic eye movements in primary glaucoma","authors":"Priyanka Maniarasu, Neetha I. R. Kuzhuppilly, Vijaya Pai H, Ramesh S. Ve, Srinivasa Varadharajan, Shonraj Ballae Ganeshrao","doi":"10.3758/s13414-024-02961-z","DOIUrl":null,"url":null,"abstract":"<div><p>Glaucoma is a progressive optic neuropathic disorder that significantly impacts the activities of daily life (ADLs) of individuals. Emerging studies indicate degenerative changes in cortical and subcortical regions in individuals with glaucoma, which are associated with cognitive processes and oculomotor control. Cognitive processes involving top-down processes such as attention, planning, task management and execution, are crucial for meeting the demands of everyday tasks, and are affected in glaucoma. This study investigated the executive functions, specifically inhibitory control (IC) and working memory (WM), in individuals with glaucoma compared to age-matched controls, using eye movements. This was achieved through four tasks sensitive to executive functions, including antisaccade, memory-guided prosaccade and antisaccade, and the Go-NoGo tasks. Saccadic eye-movement parameters were also assessed in a prosaccade task, considered as a control condition with minimal IC and WM load. The results indicated that glaucoma is associated with changes in both IC and WM. Increased anticipatory saccadic errors might be linked to inhibitory deficiencies during the preparatory stage of the saccadic suppression mechanism. The increased omission errors in the antisaccade task might be due to the lack of regulation of the WM component. Taken together, these findings provide evidence for the involvement of cognitive deficits in individuals with glaucoma.</p></div>","PeriodicalId":55433,"journal":{"name":"Attention Perception & Psychophysics","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Attention Perception & Psychophysics","FirstCategoryId":"102","ListUrlMain":"https://link.springer.com/article/10.3758/s13414-024-02961-z","RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PSYCHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Glaucoma is a progressive optic neuropathic disorder that significantly impacts the activities of daily life (ADLs) of individuals. Emerging studies indicate degenerative changes in cortical and subcortical regions in individuals with glaucoma, which are associated with cognitive processes and oculomotor control. Cognitive processes involving top-down processes such as attention, planning, task management and execution, are crucial for meeting the demands of everyday tasks, and are affected in glaucoma. This study investigated the executive functions, specifically inhibitory control (IC) and working memory (WM), in individuals with glaucoma compared to age-matched controls, using eye movements. This was achieved through four tasks sensitive to executive functions, including antisaccade, memory-guided prosaccade and antisaccade, and the Go-NoGo tasks. Saccadic eye-movement parameters were also assessed in a prosaccade task, considered as a control condition with minimal IC and WM load. The results indicated that glaucoma is associated with changes in both IC and WM. Increased anticipatory saccadic errors might be linked to inhibitory deficiencies during the preparatory stage of the saccadic suppression mechanism. The increased omission errors in the antisaccade task might be due to the lack of regulation of the WM component. Taken together, these findings provide evidence for the involvement of cognitive deficits in individuals with glaucoma.
期刊介绍:
The journal Attention, Perception, & Psychophysics is an official journal of the Psychonomic Society. It spans all areas of research in sensory processes, perception, attention, and psychophysics. Most articles published are reports of experimental work; the journal also presents theoretical, integrative, and evaluative reviews. Commentary on issues of importance to researchers appears in a special section of the journal. Founded in 1966 as Perception & Psychophysics, the journal assumed its present name in 2009.