The brain, rapid eye movement sleep, and major depressive disorder: A multimodal neuroimaging study

IF 5.3 2区 医学 Q1 CLINICAL NEUROLOGY
Siyu Liu , Jingyao Chen , Lianzi Guan , Li Xu , Huanhuan Cai , Jie Wang , Dao-min Zhu , Jiajia Zhu , Yongqiang Yu
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Abstract

Background

Evidence has established the prominent involvement of rapid eye movement (REM) sleep disturbance in major depressive disorder (MDD). However, the neural correlates of REM sleep in MDD and their clinical significance are less clear.

Methods

Cross-sectional and longitudinal polysomnography and resting-state functional MRI data were collected from 131 MDD patients and 71 healthy controls to measure REM sleep and voxel-mirrored homotopic connectivity (VMHC). Correlation and mediation analyses were performed to examine the associations between REM sleep, VMHC, and clinical variables. Moreover, we conducted spatial correlations between the neural correlates of REM sleep and a multimodal collection of reference brain maps to facilitate genetic, structural and functional annotations.

Results

MDD patients exhibited REM sleep abnormalities manifesting as higher REM sleep latency and lower REM sleep duration, which were correlated with decreased VMHC of the precentral gyrus and inferior parietal lobe and mediated their associations with more severe anxiety symptoms. Longitudinal data showed that VMHC increase of the inferior parietal lobe was related to improvement of depression symptoms in MDD patients. Spatial correlation analyses revealed that the neural correlates of REM sleep in MDD were linked to gene categories primarily involving cellular metabolic process, signal pathway, and ion channel activity as well as linked to cortical microstructure, metabolism, electrophysiology, and cannabinoid receptor.

Conclusion

These findings may add important context to the growing literature on the complex interplay between sleep and MDD, and more broadly may inform future treatment for depression via regulating sleep.
大脑、快速眼动睡眠和重度抑郁症:多模态神经成像研究。
背景:有证据表明,快速眼动(REM)睡眠障碍与重度抑郁障碍(MDD)密切相关。然而,快速眼动睡眠在重度抑郁症中的神经相关性及其临床意义尚不明确:收集了131名MDD患者和71名健康对照者的横向和纵向多导睡眠图和静息态功能磁共振成像数据,以测量REM睡眠和体素映射同位连接(VMHC)。我们进行了相关分析和中介分析,以研究快速动眼期睡眠、VMHC 和临床变量之间的关联。此外,我们还对快速动眼期睡眠的神经相关性与参考脑图的多模态集合进行了空间相关性分析,以便于进行遗传、结构和功能注释:结果:MDD患者表现出快速眼动睡眠异常,表现为快速眼动睡眠潜伏期较高和快速眼动睡眠持续时间较短,这与前中央回和顶叶下部的VMHC减少有关,并与更严重的焦虑症状相关。纵向数据显示,顶叶下部VMHC的增加与MDD患者抑郁症状的改善有关。空间相关性分析表明,MDD患者快速眼动睡眠的神经相关性与主要涉及细胞代谢过程、信号通路和离子通道活动的基因类别有关,也与皮质微结构、代谢、电生理学和大麻素受体有关:这些发现可能会为越来越多关于睡眠与多发性抑郁症之间复杂相互作用的文献增添重要的背景,更广泛地说,可能会为未来通过调节睡眠来治疗抑郁症提供依据。
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来源期刊
CiteScore
12.00
自引率
1.80%
发文量
153
审稿时长
56 days
期刊介绍: Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.
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