Three-dimensional Hill of Vision of Retinal Sensitivity in X-linked Retinitis Pigmentosa Participants under Scotopic and Mesopic Conditions.

IF 2.3 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-09-25 DOI:10.1097/IAE.0000000000004278

Antonio Yaghy, A Yasin Alibhai, Lucas R De Pretto, Darin Curtiss, David G Birch, Nadia K Waheed

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引用次数: 0

Abstract

Purpose: To evaluate the utility of three-dimensional hill of vision (HOV) analysis in assessing retinal sensitivity in X-linked retinitis pigmentosa (XLRP) patients under scotopic cyan, scotopic red, and mesopic microperimetry conditions.

Methods: Baseline microperimetry data from 31 eyes of 16 XLRP patients enrolled in the Horizon study were analyzed. HOVs were generated using Thin Plate Spline interpolation. Grid volumes of the central 20 degrees (V20) were compared between lighting conditions using the Wilcoxon Signed-Rank test with Bonferroni correction. Central and global deficits were evaluated across age groups and genotypes.

Results: The mesopic group showed the highest mean V20 (1.3 dB-Sr), followed by scotopic red (0.6 dB-Sr) and scotopic cyan (0.5 dB-Sr). Significant differences were found between mesopic and both scotopic conditions (p<0.01), but not between scotopic conditions (p=0.26). Central and global deficits were more prevalent under scotopic conditions and increased with age.

Conclusion: HOV analysis provides a comprehensive assessment of retinal sensitivity in XLRP, enabling detection of localized changes and quantification of sensitivity gradients. This volumetric approach offers advantages over traditional methods for diagnosis, monitoring progression, and evaluating treatment response.

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X 连锁视网膜色素变性参与者在苏格米氏和中视条件下视网膜灵敏度的三维视觉山丘。

目的：评估三维视丘（HOV）分析在评估X-连锁视网膜色素变性（XLRP）患者在散光青色、散光红色和中焦微透视条件下视网膜灵敏度的实用性：分析了参加 Horizon 研究的 16 名 XLRP 患者的 31 只眼睛的基线微观视力数据。使用薄板样条插值法生成 HOV。使用Wilcoxon Signed-Rank检验和Bonferroni校正比较了不同照明条件下中央20度（V20）的网格体积。对不同年龄组和基因型的中心和整体缺陷进行了评估：中视组的平均 V20 值最高（1.3 dB-Sr），其次是散光红色（0.6 dB-Sr）和散光青色（0.5 dB-Sr）。中视和散光条件之间存在显著差异（p 结论：HOV 分析可全面评估 XLRP 的视网膜灵敏度，检测局部变化并量化灵敏度梯度。在诊断、监测病情发展和评估治疗反应方面，这种体积分析方法比传统方法更具优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.