Quantification of capillary blood flow speeds in diabetic retinopathy using variable interscan time analysis (VISTA) OCTA.

IF 2.3 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-09-25 DOI:10.1097/IAE.0000000000004279

Yunchan Hwang, Hiroyuki Takahashi, Jungeun Won, Antonio Yaghy, Anna Marmalidou, Stephanie M Kaiser, Muhammad Usman Jamil, Caroline R Baumal, Nadia K Waheed, James G Fujimoto

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引用次数: 0

Abstract

Purpose: To investigate retinal capillary plexus capillary flow speed and vessel density in diabetic retinopathy (DR) and normal subjects using variable interscan time analysis (VISTA) optical coherence tomography angiography (OCTA).

Methods: High speed swept source OCTA imaging using multiple interscan times was performed over a 5 mm x 5 mm field-of-view with 600 kHz A-scan rate. Second-generation VISTA OCTA was used to measure a surrogate marker for capillary blood flow speed, VISTA flow speed (VFS), in the superficial and intermediate capillary plexuses, (SCP + ICP)VFS, and deep capillary plexus, DCPVFS. Vessel density was measured using OCTA.

Results: Fifty-seven eyes with different DR severity and 37 normal eyes were analyzed. VISTA OCTA provided diverse blood flow speed information, including pseudo-color OCTA and mean flow speed in different regions. Both DCPVFS and DCPVFS/(SCP + ICP)VFS were higher in DR compared to normal eyes. Elevated DCPVFS correlated with decreased DCP vessel density in non-proliferative DR.

Conclusion: VISTA OCTA can measure a quantitative biomarker for blood flow speed alterations in DR and normal eyes as well as the association with vessel density in different capillary plexuses. VISTA OCTA is promising for studies of pathogenesis and early flow alterations which may precede non-perfusion.

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利用可变扫描间时间分析（VISTA）OCTA 对糖尿病视网膜病变中的毛细血管血流速度进行量化。

目的：使用可变扫描间时间分析（VISTA）光学相干断层血管成像（OCTA）技术，研究糖尿病视网膜病变（DR）和正常人视网膜毛细血管丛的毛细血管流速和血管密度。方法：在 5 mm x 5 mm 视场范围内，以 600 kHz A 扫描速率，使用多重扫描间时间进行高速扫源 OCTA 成像。第二代 VISTA OCTA 用于测量浅层和中层毛细血管丛（SCP + ICP）VFS 和深层毛细血管丛（DCPVFS）中毛细血管血流速度的替代标记--VISTA 流速（VFS）。使用 OCTA 测量血管密度：结果：分析了 57 只具有不同 DR 严重程度的眼睛和 37 只正常眼睛。VISTA OCTA 提供了多种血流速度信息，包括伪彩色 OCTA 和不同区域的平均血流速度。与正常眼相比，DR 患者的 DCPVFS 和 DCPVFS/(SCP + ICP)VFS 均较高。在非增殖性DR中，DCPVFS的升高与DCP血管密度的降低相关：结论：VISTA OCTA 可以测量 DR 和正常眼球中血流速度变化的定量生物标志物，以及与不同毛细血管丛中血管密度的关联。VISTA OCTA 在研究发病机制和早期血流改变（可能发生在非灌注之前）方面大有可为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.