Charting the ligandable proteome for stereoselective interactions

IF 19.2 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nature chemistry Pub Date : 2024-10-01 DOI:10.1038/s41557-024-01639-1

John Paul Pezacki, Eryn Lundrigan, Parrish Evers, Spencer Uguccioni

引用次数: 0

Abstract

Determining the ligandability of the human proteome can provide key insights to characterize biological processes and promote drug discovery. Now, multi-tiered activity-based protein profiling provides comprehensive proteomic maps of chiral small-molecule interactions. Over 300 distinctive proteins were identified to ligand tryptoline acrylamides, including stereoselective and site-specific events.

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绘制立体选择性相互作用的可配体蛋白质组图

确定人类蛋白质组的配体性可以为描述生物过程和促进药物发现提供重要的见解。现在，基于活性的多层次蛋白质分析提供了手性小分子相互作用的全面蛋白质组图谱。研究发现了 300 多种与胰肽丙烯酰胺配体的独特蛋白质，包括立体选择性和位点特异性事件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature chemistry 化学-化学综合

CiteScore

29.60

自引率

1.40%

发文量

226

审稿时长

1.7 months

期刊介绍： Nature Chemistry is a monthly journal that publishes groundbreaking and significant research in all areas of chemistry. It covers traditional subjects such as analytical, inorganic, organic, and physical chemistry, as well as a wide range of other topics including catalysis, computational and theoretical chemistry, and environmental chemistry. The journal also features interdisciplinary research at the interface of chemistry with biology, materials science, nanotechnology, and physics. Manuscripts detailing such multidisciplinary work are encouraged, as long as the central theme pertains to chemistry. Aside from primary research, Nature Chemistry publishes review articles, news and views, research highlights from other journals, commentaries, book reviews, correspondence, and analysis of the broader chemical landscape. It also addresses crucial issues related to education, funding, policy, intellectual property, and the societal impact of chemistry. Nature Chemistry is dedicated to ensuring the highest standards of original research through a fair and rigorous review process. It offers authors maximum visibility for their papers, access to a broad readership, exceptional copy editing and production standards, rapid publication, and independence from academic societies and other vested interests. Overall, Nature Chemistry aims to be the authoritative voice of the global chemical community.