Body-worn and self-powered flexible optoelectronic device for metronomic photodynamic therapy

IF 12.3 1区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Jianhong Zhang, Xinhui Mao, Qingyan Jia, Renhao Nie, Yangyang Gao, Kai Tao, Honglong Chang, Peng Li, Wei Huang
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Abstract

Photodynamic therapy (PDT) as a clinical method relies on appropriate light delivery to activate photosensitizers, usually necessitates the utilization of cumbersome surgical instruments and high irradiation intensity, along with the requirement for hospitalization. To extend the applicability of PDT beyond hospital for better patient mobility, we design a wearable and self-powered metronomic PDT (mPDT) system for chronic wound infection treatment. A flexible alternative current electroluminescent (ACEL) device is constructed through sandwiching an emissive layer between conductive hydrogel electrodes. This ACEL device works as a therapeutic patch by loading photosensitizer (PS) in its bottom hydrogel electrode, thus aviods the intravenous administration to patients. Under the triboelectric nanogenerator generated AC pulse, the electroluminescence produced from emissive layer can be absorbed by the PS-loaded electrode to generate reactive oxygen species for mPDT. Benefited from its arbitrary tailorability, this device can be customized into on-demand shapes and sizes. Using diabetic infected wound as a model condition, this ACEL mPDT device effectively eliminates drug-resistant bacteria and accelerates wound healing. Thus, the body-worn optoelectronic device successfully avoids the utilization of extracorporeal physical light and power sources, providing a promising strategy for convenient, user-friendly, and prolonged treatment of superficial diseases.

Abstract Image

Abstract Image

用于节拍光动力疗法的体戴式自供电柔性光电设备
光动力疗法(PDT)作为一种临床方法,依赖于适当的光传递来激活光敏剂,通常需要使用笨重的手术器械和高强度的照射,而且需要住院治疗。为了将光化学疗法的适用范围扩大到医院以外,使病人有更好的行动能力,我们设计了一种可穿戴、自供电的节律光化学疗法(mPDT)系统,用于慢性伤口感染治疗。我们在导电水凝胶电极之间夹了一层发射层,从而构建了一个灵活的替代电流电致发光(ACEL)装置。通过在底部水凝胶电极中加入光敏剂(PS),这种替代电流电致发光(ACEL)装置可用作治疗贴片,从而避免了患者的静脉注射。在三电纳米发电机产生的交流脉冲下,发射层产生的电致发光可被负载 PS 的电极吸收,从而产生活性氧,用于 mPDT。得益于其任意定制性,该装置可按需定制形状和尺寸。以糖尿病感染伤口为模型条件,这种 ACEL mPDT 设备可有效消除耐药细菌并加速伤口愈合。因此,这种体戴式光电设备成功地避免了使用体外物理光源和电源,为方便、易用和延长浅表疾病的治疗时间提供了一种前景广阔的策略。
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来源期刊
CiteScore
17.10
自引率
4.80%
发文量
91
审稿时长
6 weeks
期刊介绍: npj Flexible Electronics is an online-only and open access journal, which publishes high-quality papers related to flexible electronic systems, including plastic electronics and emerging materials, new device design and fabrication technologies, and applications.
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