Astrocytes are enablers of brain metastases

IF 17.3 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2024-09-30 DOI:10.1038/s41556-024-01516-6

Livia Garzia

引用次数: 0

Abstract

Circulating tumour cells from primary carcinomas may reach the brain and establish metastases. In the brain parenchyma, tumour cells initiate extensive interactions with resident astrocytes, microglia and neurons, forming a niche where tumour cells can thrive. A new study reveals a previously unknown type of astrocyte–tumour cell interaction.

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星形胶质细胞是脑转移的助推器

原发性癌症的循环肿瘤细胞可能会进入大脑并形成转移。在脑实质中，肿瘤细胞会与驻留的星形胶质细胞、小胶质细胞和神经元产生广泛的相互作用，形成一个肿瘤细胞可以生长的 "生态位"。一项新的研究揭示了一种以前未知的星形胶质细胞-肿瘤细胞相互作用类型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology