Inference and applications of ancestral recombination graphs

IF 39.1 1区 生物学 Q1 GENETICS & HEREDITY
Rasmus Nielsen, Andrew H. Vaughn, Yun Deng
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引用次数: 0

Abstract

Ancestral recombination graphs (ARGs) summarize the complex genealogical relationships between individuals represented in a sample of DNA sequences. Their use is currently revolutionizing the field of population genetics and is leading to the development of powerful new methods to elucidate individual and population genetic processes, including population size history, migration, admixture, recombination, mutation and selection. In this Review, we introduce the readers to the structure of ARGs and discuss how they relate to processes such as recombination and genetic drift. We explore differences and similarities between methods of estimating ARGs and provide concrete illustrative examples of how ARGs can be used to elucidate population-level processes.

Abstract Image

祖先重组图的推断与应用
祖先重组图(ARGs)概括了 DNA 序列样本中个体之间复杂的系谱关系。目前,ARG 的使用正在给群体遗传学领域带来革命性的变化,并促使人们开发出功能强大的新方法来阐明个体和群体的遗传过程,包括群体规模历史、迁移、混杂、重组、变异和选择。在这篇综述中,我们将向读者介绍ARGs的结构,并讨论它们与重组和遗传漂变等过程的关系。我们探讨了 ARGs 估算方法的异同,并提供了具体的示例,说明如何利用 ARGs 阐明种群水平的过程。
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来源期刊
Nature Reviews Genetics
Nature Reviews Genetics 生物-遗传学
CiteScore
57.40
自引率
0.50%
发文量
113
审稿时长
6-12 weeks
期刊介绍: At Nature Reviews Genetics, our goal is to be the leading source of reviews and commentaries for the scientific communities we serve. We are dedicated to publishing authoritative articles that are easily accessible to our readers. We believe in enhancing our articles with clear and understandable figures, tables, and other display items. Our aim is to provide an unparalleled service to authors, referees, and readers, and we are committed to maximizing the usefulness and impact of each article we publish. Within our journal, we publish a range of content including Research Highlights, Comments, Reviews, and Perspectives that are relevant to geneticists and genomicists. With our broad scope, we ensure that the articles we publish reach the widest possible audience. As part of the Nature Reviews portfolio of journals, we strive to uphold the high standards and reputation associated with this esteemed collection of publications.
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