Impact of Glycine Powder Air-Abrasive Debridement on Peri-Implant Mucositis: A Randomized Control Trial of Clinical, Microbial, and Immunological Changes

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research Pub Date : 2024-09-28 DOI:10.1111/clr.14361

Brian Partido, Shweta Saraswat, Purnima S. Kumar

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引用次数: 0

Abstract

Aim

Peri-implant mucositis, a dysbiosis-driven inflammatory disease, is a precursor to peri-implantitis, underscoring the need for early disease management. Therefore, we investigated the efficacy of glycine powder in resolving clinical inflammation and restoring host-microbial homeostasis.

Methods

Thirty subjects were randomized to receive either glycine powder air-abrasive debridement or ultrasonic instrumentation. Clinical parameters (probe depth [PD], modified Sulcular Bleeding Index [mSBI], modified Plaque Index [mPlI]), biofilm and peri-implant crevicular fluid were collected at baseline and at 1-day, 1-, 3-, 6-weeks and 3- and 6-months post-therapy. Microbial recolonization was examined using 16S rDNA sequencing and immune response was semi-quantified using a bead-based 17-plex microarray.

Results

At 6-months, both groups demonstrated non-significant reductions in mSBI when compared to baseline (p > 0.05, Wald test, mixed model for repeated measures). However, mSBI and PD decreased in the test group from week-1 to 3-months, while control group decreased at 1- and 3-weeks only. mSBI was lower in the test group when compared to controls from Week-1 to 3-months, while PD differed between groups at 6 weeks and 3-months. Glycine group demonstrated significant microbial shifts after 24-h, increases in species richness and health-compatible species, and loss of pathobionts (p < 0.001, Dunn test). Pro-inflammatory cytokines decreased from 1- to 6-weeks or 3-months (p < 0.05, Wald test). Comparable results were obtained in the ultrasonic group at 3-weeks and sustained over 6-weeks post-therapy.

Conclusions

Glycine therapy leads to early and sustained change in host-microbial interactions when compared to ultrasonics, however, the changes wrought by both therapies were sustained for a maximum of 3 months.

Trial Registration

ClinicalTrials.gov identifier: NCT05810558

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甘氨酸粉空气磨擦清创对种植体周围黏膜炎的影响：临床、微生物和免疫学变化的随机对照试验

目的种植体周围粘膜炎是一种由菌群失调引起的炎症性疾病，是种植体周围炎的前兆，因此需要尽早治疗。因此，我们研究了甘氨酸粉在消除临床炎症和恢复宿主-微生物平衡方面的疗效。临床参数（探针深度[PD]、改良龈沟出血指数[mSBI]、改良斑块指数[mPlI]）、生物膜和种植体周围缝隙液分别在基线期、治疗后1天、1周、3周、6周、3个月和6个月时收集。使用 16S rDNA 测序法检测微生物的重新定殖情况，并使用基于微珠的 17-plex 微阵列对免疫反应进行半定量分析。结果6 个月时，与基线相比，两组的 mSBI 均无显著降低（p > 0.05，Wald 检验，重复测量混合模型）。然而，测试组的 mSBI 和 PD 在第 1 周至 3 个月期间均有所下降，而对照组仅在第 1 周和 3 周有所下降。甘氨酸组在 24 小时后微生物发生了显著变化，物种丰富度和健康兼容物种增加，病原菌减少（p < 0.001，Dunn 检验）。促炎细胞因子从 1 周到 6 周或 3 个月有所减少（p < 0.05，Wald 检验）。结论与超声波疗法相比，甘氨酸疗法能及早、持续地改变宿主与微生物之间的相互作用，但两种疗法带来的变化最多只能维持 3 个月：NCT05810558

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来源期刊

Clinical Oral Implants Research 医学-工程：生物医学

CiteScore

7.70

自引率

11.60%

发文量

149

审稿时长

3 months

期刊介绍： Clinical Oral Implants Research conveys scientific progress in the field of implant dentistry and its related areas to clinicians, teachers and researchers concerned with the application of this information for the benefit of patients in need of oral implants. The journal addresses itself to clinicians, general practitioners, periodontists, oral and maxillofacial surgeons and prosthodontists, as well as to teachers, academicians and scholars involved in the education of professionals and in the scientific promotion of the field of implant dentistry.