Health state utility is substantially reduced with an increasing burden of patient-reported symptoms in eosinophilic esophagitis.

Abstract

BACKGROUND We aimed to estimate health state utility in eosinophilic esophagitis (EoE) by histologic activity and assess association with disease parameters. METHODS In this cross-sectional study, we measured health state utility by time trade-off and assessed symptoms with the EoE Symptom Activity Index (EEsAI). RESULTS In 51 adults with EoE, mean utility was 0.91 (95% CI 0.86, 0.95). Utility was numerically worse in patients with dilation or a smaller stricture diameter. With each ten-point improvement in EEsAI, utility increased by 0.03 (95% CI 0.01, 0.05). DISCUSSION EoE is associated with reduced health state utility, with symptoms most strongly predicting valuation.