Sujan Banik , Antara Ghosh , Tomoyuki Takano , Masao Tsukamoto , Soo Takasu , Masaki Honda
{"title":"Geometrical isomers of lutein and fucoxanthin: Unveiling their antioxidant potentials and skin-related biological activities","authors":"Sujan Banik , Antara Ghosh , Tomoyuki Takano , Masao Tsukamoto , Soo Takasu , Masaki Honda","doi":"10.1016/j.focha.2024.100817","DOIUrl":null,"url":null,"abstract":"<div><div>Although carotenoids are most commonly found in dietary sources as all-<em>E</em>-isomers, some carotenoids accumulate in the skin as <em>Z</em>-isomers; their roles are largely unknown. This study investigated the effects of <em>E/Z</em>-isomers of lutein and fucoxanthin, two xanthophyll carotenoids, on their antioxidant potential and skin-related biological activities. Evaluation of ultraviolet (UV)-blocking abilities demonstrated the superior performance of <em>Z</em>-isomer-rich lutein and fucoxanthin against UV-A and UV-B radiation, with <em>Z</em>-isomer-rich lutein exhibiting higher UV-B protection. Antioxidant assays revealed that all-<em>E</em>- and <em>Z</em>-isomer-rich lutein and fucoxanthin had potent singlet oxygen and hydroxyl radical scavenging activities. Moreover, <em>Z</em>-isomer-rich lutein and fucoxanthin exhibited enhanced lipid peroxidation scavenging compared with their all-<em>E</em> counterparts. Both isomers of lutein and fucoxanthin exhibited potent skin-antiaging and skin-whitening effects in several <em>in vitro</em> assays, including anti-elastase and anti-tyrosinase activities. These findings suggest that geometric isomers may enhance the therapeutic efficacy of carotenoids in skin care applications.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"5 ","pages":"Article 100817"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food chemistry advances","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772753X24002120","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Although carotenoids are most commonly found in dietary sources as all-E-isomers, some carotenoids accumulate in the skin as Z-isomers; their roles are largely unknown. This study investigated the effects of E/Z-isomers of lutein and fucoxanthin, two xanthophyll carotenoids, on their antioxidant potential and skin-related biological activities. Evaluation of ultraviolet (UV)-blocking abilities demonstrated the superior performance of Z-isomer-rich lutein and fucoxanthin against UV-A and UV-B radiation, with Z-isomer-rich lutein exhibiting higher UV-B protection. Antioxidant assays revealed that all-E- and Z-isomer-rich lutein and fucoxanthin had potent singlet oxygen and hydroxyl radical scavenging activities. Moreover, Z-isomer-rich lutein and fucoxanthin exhibited enhanced lipid peroxidation scavenging compared with their all-E counterparts. Both isomers of lutein and fucoxanthin exhibited potent skin-antiaging and skin-whitening effects in several in vitro assays, including anti-elastase and anti-tyrosinase activities. These findings suggest that geometric isomers may enhance the therapeutic efficacy of carotenoids in skin care applications.