Magnesium borate-glasses for biomedical application: Physicochemical and in vitro bioactive properties, antibacterial activity and cell viability

IF 3.2 3区材料科学 Q1 MATERIALS SCIENCE, CERAMICS

Journal of Non-crystalline Solids Pub Date : 2024-09-28 DOI:10.1016/j.jnoncrysol.2024.123239

Maria N. Queiroz , Taís S. Morais , Tatielle G. Dias , Jaqueline D.S. Barros , Richard P. Dutra , Aramys S. Reis , Alan S. de Menezes , Alysson Steimacher , Franciana Pedrochi

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Abstract

Borate bioactive glasses doped with magnesium oxide (MgO) were synthetized by melt-quenching method and evaluated their physicochemical and in vitro bioactive properties. The glasses were characterized by volumetric density, DTA, XRD and FTIR techniques. In vitro bioactivity was evaluated by SBF immersion test. Cytocompatibility tests were performed on RAW-247 murine macrophage cells. Antibacterial activity was evaluated by the agar disk diffusion method. The XRD results confirm the amorphous nature of the glasses. FTIR analysis showed that the MgO addition modifies the glass network, causing changes in the volumetric density, molar volume, and thermal properties. The in vitro bioactivity was confirmed by XRD, FTIR, and SEM-EDS analyses; all samples showed the formation of biological apatites. All samples are non-cytotoxic and presented good antibacterial activity against S. aureus and P. aeruginosa bacteria. Therefore, all samples are good candidates for biomedical applications, mainly in bone regeneration.

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用于生物医学的硼酸镁玻璃：理化和体外生物活性特性、抗菌活性和细胞活力

采用熔融淬火法合成了掺杂氧化镁（MgO）的硼酸盐生物活性玻璃，并对其物理化学和体外生物活性特性进行了评估。通过体积密度、DTA、X 射线衍射和傅立叶变换红外技术对玻璃进行了表征。体外生物活性通过 SBF 浸泡测试进行评估。在 RAW-247 鼠巨噬细胞上进行了细胞相容性测试。抗菌活性通过琼脂盘扩散法进行评估。XRD 结果证实了玻璃的无定形性质。傅立叶变换红外分析表明，氧化镁的加入改变了玻璃网络，导致体积密度、摩尔体积和热性能发生变化。X射线衍射、傅立叶变换红外和扫描电镜-电子显微镜分析证实了体外生物活性；所有样品都显示形成了生物磷灰石。所有样品均无细胞毒性，对金黄色葡萄球菌和绿脓杆菌具有良好的抗菌活性。因此，所有样品都是生物医学应用（主要是骨再生）的理想候选材料。

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来源期刊

Journal of Non-crystalline Solids 工程技术-材料科学：硅酸盐

CiteScore

6.50

自引率

11.40%

发文量

576

审稿时长

35 days

期刊介绍： The Journal of Non-Crystalline Solids publishes review articles, research papers, and Letters to the Editor on amorphous and glassy materials, including inorganic, organic, polymeric, hybrid and metallic systems. Papers on partially glassy materials, such as glass-ceramics and glass-matrix composites, and papers involving the liquid state are also included in so far as the properties of the liquid are relevant for the formation of the solid. In all cases the papers must demonstrate both novelty and importance to the field, by way of significant advances in understanding or application of non-crystalline solids; in the case of Letters, a compelling case must also be made for expedited handling.