Lymphangiogenesis: novel strategies to promote cutaneous wound healing

IF 6.3 1区医学 Q1 DERMATOLOGY

Burns & Trauma Pub Date : 2024-09-27 DOI:10.1093/burnst/tkae040

Yang Jian, Yanqi Li, Yanji Zhang, Mingyuan Tang, Mingfu Deng, Chenxiaoxiao Liu, Maolin Cheng, Shune Xiao, Chengliang Deng, Zairong Wei

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引用次数: 0

Abstract

The cutaneous lymphatic system regulates tissue inflammation, fluid balance and immunological responses. Lymphangiogenesis or lymphatic dysfunction may lead to lymphedema, immune deficiency, chronic inflammation etc. Tissue regeneration and healing depend on angiogenesis and lymphangiogenesis during wound healing. Tissue oedema and chronic inflammation can slow wound healing due to impaired lymphangiogenesis or lymphatic dysfunction. For example, impaired lymphangiogenesis or lymphatic dysfunction has been detected in nonhealing wounds such as diabetic ulcers, venous ulcers and bedsores. This review summarizes the structure and function of the cutaneous lymphatic vessel system and lymphangiogenesis in wounds. Furthermore, we review wound lymphangiogenesis processes and remodelling, especially the influence of the inflammatory phase. Finally, we outline how to control lymphangiogenesis to promote wound healing, assess the possibility of targeting lymphangiogenesis as a novel treatment strategy for chronic wounds and provide an analysis of the possible problems that need to be addressed.

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淋巴管生成：促进皮肤伤口愈合的新策略

皮肤淋巴系统调节组织炎症、体液平衡和免疫反应。淋巴管生成或淋巴功能障碍可导致淋巴水肿、免疫缺陷、慢性炎症等。组织的再生和愈合取决于伤口愈合过程中的血管生成和淋巴管生成。由于淋巴管生成受损或淋巴功能障碍，组织水肿和慢性炎症会导致伤口愈合缓慢。例如，在糖尿病溃疡、静脉溃疡和褥疮等无法愈合的伤口中就发现了淋巴管生成受损或淋巴功能障碍。本综述概述了皮肤淋巴管系统的结构和功能以及伤口中的淋巴管生成。此外，我们还回顾了伤口淋巴管生成过程和重塑，尤其是炎症阶段的影响。最后，我们概述了如何控制淋巴管生成以促进伤口愈合，评估了以淋巴管生成为目标作为慢性伤口新型治疗策略的可能性，并分析了需要解决的可能问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Burns & Trauma 医学-皮肤病学

CiteScore

8.40

自引率

9.40%

发文量

186

审稿时长

6 weeks

期刊介绍： The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.