Associations of urinary nicotine metabolites and essential metals with metabolic syndrome in older adults: The mediation effect of insulin resistance

IF 12.2 1区环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL

Journal of Hazardous Materials Pub Date : 2024-09-26 DOI:10.1016/j.jhazmat.2024.135969

Zhihui Guo, Peiyi Liu, Tian Li, Erwei Gao, Junye Bian, Xiaohu Ren, Benhong Xu, Xiao Chen, Haiyan Huang, Jianjun Liu, Xifei Yang, Shaoyou Lu

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Abstract

Exposure to tobacco smoke and essential metals is linked with metabolic syndrome (MS). However, the joint effect of them on MS in older adults and the underlying mechanisms are still unclear. This large-scale study measured the urinary concentrations of 8 nicotine metabolites and 8 essential metals in 4564 older adults from Shenzhen, China. The biomarker of insulin resistance, triglyceride-glucose index (TyG), was also calculated. Restricted cubic splines (RCS), Bayesian kernel machine regression and quantile-based g-computation were used to access the single and joint effects of urinary nicotine metabolites and essential metals on MS and insulin resistance. Mediation analysis was performed to investigate the role of TyG in these relationships.Single urinary nicotine metabolite and essential metal had non-linear relationships with MS in RCS. The overall effect of urinary nicotine metabolites and essential metals was positively associated with MS. Urinary zinc (52.2%) and copper (20.1%) were the major contributors to MS, whereas molybdenum had a negative association with MS. TyG mediated 64.7% of the overall effect of urinary nicotine metabolites and essential metals on MS. Overall, the mixture of urinary nicotine metabolites and essential metals had a dose-response relationship with MS. Insulin resistance was as a crucial mediated pathway in this association.

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尿液中尼古丁代谢物和必需金属与老年人代谢综合征的关系：胰岛素抵抗的中介效应

接触烟草烟雾和基本金属与代谢综合征（MS）有关。然而，它们对老年人代谢综合征的共同影响及其内在机制仍不清楚。这项大规模研究测量了中国深圳 4564 名老年人尿液中 8 种尼古丁代谢物和 8 种必需金属的浓度。同时还计算了胰岛素抵抗的生物标志物--甘油三酯-葡萄糖指数（TyG）。利用限制立方样条（RCS）、贝叶斯核机器回归和基于量子的 g 计算方法，研究了尿液中尼古丁代谢物和必需金属对 MS 和胰岛素抵抗的单一和联合影响。尿中尼古丁代谢物和必需金属与RCS中的MS存在非线性关系。尿液中尼古丁代谢物和必需金属的总体效应与 MS 呈正相关。尿液中的锌（52.2%）和铜（20.1%）是导致多发性硬化的主要因素，而钼与多发性硬化呈负相关。在尿液中尼古丁代谢物和必需金属对多发性硬化症的总体影响中，64.7%是由TyG介导的。总体而言，尿液中尼古丁代谢物和必需金属的混合物与多发性硬化呈剂量反应关系。胰岛素抵抗是这一关联的关键介导途径。

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来源期刊

Journal of Hazardous Materials 工程技术-工程：环境

CiteScore

25.40

自引率

5.90%

发文量

3059

审稿时长

58 days

期刊介绍： The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.