Generalized paroxysmal fast activity in a cohort of patients with epilepsy with eyelid myoclonia

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2024-09-19 DOI:10.1016/j.clinph.2024.09.016

Haipo Yang, Shuang Wang

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引用次数: 0

Abstract

Objective

This study aimed to analyze and summarize the characteristics of generalized paroxysmal fast activity (GPFA) via electroencephalography (EEG) in patients with epilepsy with eyelid myoclonia (EEM) and to determine its relationship with clinical outcome.

Methods

Patients with EEM were selected from our EEG database. The collected data included detailed clinical information, factors that triggered GPFA, and the relationship between GPFA and eyelid myoclonia seizures. The clinical data and EEG characteristics of patients with and without GPFA were compared.

Results

Forty-seven patients with EEM were identified according to the clinical criteria, of whom 18 (38.3%) exhibited GPFA. GPFA can occur ictally or interictally. The difference in the response to antiseizure medication (ASM) between EEM patients with and without GPFA suggested that patients who had GPFA on EEG might have easier seizure control.

Conclusion

In our study, 38.3% of EEM patients had GPFA on EEG. GPFA is an EEG pattern in individuals with EEM that can cause eyelid myoclonia. EEM patients with GPFA on their EEG had easier seizure control than those without GPFA.

Significance

This study summarized the incidence and electroclinical features of GPFA in a cohort of patients with EEM.

查看原文本刊更多论文

一组伴有眼睑肌张力障碍的癫痫患者的全身阵发性快速活动

目的本研究旨在通过脑电图（EEG）分析和总结眼睑肌张力障碍性癫痫（EEM）患者全身阵发性快速活动（GPFA）的特征，并确定其与临床结果的关系。收集的数据包括详细的临床信息、诱发 GPFA 的因素以及 GPFA 与眼睑肌阵挛发作之间的关系。结果根据临床标准确定了47名EEM患者，其中18人（38.3%）表现出GPFA。GPFA 可发生在发作期或发作间期。有和没有 GPFA 的 EEM 患者对抗癫痫药物（ASM）的反应不同，这表明脑电图上有 GPFA 的患者可能更容易控制癫痫发作。GPFA是EEM患者的一种脑电图模式，可导致眼睑肌张力障碍。与没有 GPFA 的 EEM 患者相比，脑电图显示 GPFA 的 EEM 患者更容易控制癫痫发作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.