The different functions of V-ATPase subunits in adipocyte differentiation and their expression in obese mice

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical and biophysical research communications Pub Date : 2024-09-24 DOI:10.1016/j.bbrc.2024.150733

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引用次数: 0

Abstract

Background

Obesity is a significant global public health issue linked to numerous chronic diseases, including diabetes, cardiovascular conditions, and various cancers. The vacuolar H + ATPase, a multi-subunit enzyme complex involved in maintaining pH balance, has been implicated in various health conditions, including obesity-related diseases.

Method

This study conducts a comprehensive analysis of V-ATPase subunits' roles in adipogenesis within the context of obesity, using knockdown and RNAseq technologies.

Result

This study conducts a comprehensive analysis of V-ATPase subunits' roles in adipogenesis, highlighting specific subunits, v0d2 and v1a, which show significant expression alterations. Our findings reveal that v1a plays a crucial role in adipocyte differentiation through pathways related to steroid and cholesterol metabolism.

Conclusion

This study provides a comprehensive analysis of the roles played by V-ATPase subunits in adipogenesis and finds the critical role of V-ATPase subunits, particularly v1a, in the differentiation of adipocytes and their potential impact on obesity.

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V-ATPase 亚基在脂肪细胞分化中的不同功能及其在肥胖小鼠体内的表达

背景肥胖是一个重大的全球公共卫生问题，与许多慢性疾病（包括糖尿病、心血管疾病和各种癌症）有关。方法本研究利用基因敲除和 RNAseq 技术全面分析了 V-ATPase 亚基在肥胖背景下脂肪生成过程中的作用。结果本研究对V-ATP酶亚基在脂肪生成中的作用进行了全面分析，重点研究了特定亚基（v0d2和v1a）在脂肪生成中的显著表达变化。结论本研究全面分析了 V-ATPase 亚基在脂肪生成过程中的作用，发现 V-ATPase 亚基（尤其是 v1a）在脂肪细胞分化过程中起着关键作用，对肥胖症有潜在影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemical and biophysical research communications 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

1400

审稿时长

14 days

期刊介绍： Biochemical and Biophysical Research Communications is the premier international journal devoted to the very rapid dissemination of timely and significant experimental results in diverse fields of biological research. The development of the "Breakthroughs and Views" section brings the minireview format to the journal, and issues often contain collections of special interest manuscripts. BBRC is published weekly (52 issues/year).Research Areas now include: Biochemistry; biophysics; cell biology; developmental biology; immunology ; molecular biology; neurobiology; plant biology and proteomics