B cell memory of Immunoglobulin E (IgE) antibody responses in allergy

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2024-09-27 DOI:10.1016/j.coi.2024.102488

Weslley Fernandes-Braga, Maria A Curotto de Lafaille

引用次数: 0

Abstract

Immunoglobulin E (IgE)-mediated allergic diseases are driven by high-affinity allergen-specific IgE antibodies. IgE antibodies bind to Fc epsilon receptors on mast cells, prompting their degranulation and initiating inflammatory reactions upon allergen crosslinking. While most IgE-producing plasma cells have short lifespans, and IgE memory B cells are exceedingly rare, studies have indicated that non-IgE-expressing type 2–polarized IgG memory B cells serve as a reservoir of IgE memory in allergies. This review explores the B cell populations underlying IgE-mediated allergies, including the cellular and molecular processes that drive IgE class switching from non-IgE memory B cells. It highlights emerging evidence from human studies identifying type 2 IgG memory B cells as the source of pathogenic IgE in allergic responses.

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过敏症中免疫球蛋白 E (IgE) 抗体反应的 B 细胞记忆

免疫球蛋白 E（IgE）介导的过敏性疾病是由高亲和力的过敏原特异性 IgE 抗体引起的。IgE 抗体与肥大细胞上的 Fc epsilon 受体结合，促使肥大细胞脱颗粒，并在过敏原交联后引发炎症反应。虽然大多数产生 IgE 的浆细胞寿命很短，IgE 记忆 B 细胞也极为罕见，但研究表明，非 IgE 表达的 2 型极化 IgG 记忆 B 细胞是过敏症中的 IgE 记忆库。本综述探讨了 IgE 介导的过敏症的基础 B 细胞群，包括驱动非 IgE 记忆 B 细胞 IgE 类别转换的细胞和分子过程。它强调了人类研究中新出现的证据，即 2 型 IgG 记忆 B 细胞是过敏反应中致病性 IgE 的来源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

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