Assessing the association between common functional Nuclear Factor Kappa-b gene polymorphisms (NFKB1, NFKBIZ, NFKBIA) and Alzheimer´s disease

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2024-09-23 DOI:10.1016/j.bbr.2024.115264

Daniel Vazquez-Coto , Sergio Perez-Oliveira , Manuel Menéndez-González , Eliecer Coto , Victoria Álvarez

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引用次数: 0

Abstract

The Nuclear Factor Kappa-b (NF-Κb) pathway has been implicated in the pathogenesis of Alzheimer´s disease (AD). We determined whether common variants in the NF-Κb genes were associated with the risk of developing late-onset AD (LOAD). A total of 639 Spanish LOAD and 500 controls were genotyped for the NFKB1 rs28362491/rs7667496, NFKBIA rs696, NFKBIZ rs3217713 and APOE-Ɛ2/3/4 polymorphisms. Rs7667496 C was increased in the patients (p<0.001) with the CC genotype showing a significant risk (CC vs T+, OR= 1.58, 95 %CI=1.25–2.01). The CC genotype was significantly associated with LOAD after correction by APOE-4+ genotypes, age and sex (p=0.0003, OR=1.88, 95 %CI=1.28–2.78). The NFKB1 rs28362491 I - rs7667496 C haplotype was significantly increased in the patients (p=0.02). NFKBIA and NFKBIZ variants were not associated with the risk of LOAD in our population. In conclusion, NFKB1 variants were associated with the risk of LOAD in our population. This finding encourages further studies to determine the involvement of the NF-kB components in LOAD.

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评估常见功能性核因子卡巴-b 基因多态性（NFKB1、NFKBIZ、NFKBIA）与阿尔茨海默病之间的关系

核因子卡巴-b（NF-Κb）通路与阿尔茨海默病（AD）的发病机制有关。我们确定了 NF-Κb 基因中的常见变异是否与晚发性阿兹海默症（LOAD）的发病风险有关。我们对 639 名西班牙 LOAD 患者和 500 名对照者进行了 NFKB1 rs28362491/rs7667496、NFKBIA rs696、NFKBIZ rs3217713 和 APOE-Ɛ2/3/4 多态性基因分型。Rs7667496 C 在患者中增加（p<0.001），CC 基因型显示出显著风险（CC vs T+，OR= 1.58，95 %CI=1.25-2.01）。经 APOE-4+ 基因型、年龄和性别校正后，CC 基因型与 LOAD 显著相关（p=0.0003，OR=1.88，95 %CI=1.28-2.78）。患者的 NFKB1 rs28362491 I - rs7667496 C 单倍型显著增加（p=0.02）。在我们的人群中，NFKBIA 和 NFKBIZ 变体与 LOAD 风险无关。总之，在我们的人群中，NFKB1变异与LOAD的风险有关。这一发现有助于进一步研究NF-kB成分在LOAD中的参与情况。

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.