Structural remodeling of the inactive X chromosome during early mouse development

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2024-09-27 DOI:10.1038/s41588-024-01936-y

Edda G. Schulz, Alexandra Martitz

引用次数: 0

Abstract

The mammalian inactive X chromosome shows unusual folding dominated by large-scale structures. A study finds a megadomain structure with a boundary at the Xist locus, preceding the well-known Dxz4-separated megadomains in somatic cells.

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小鼠早期发育过程中无活性 X 染色体的结构重塑

哺乳动物的非活性 X 染色体显示出以大规模结构为主的不寻常折叠。一项研究发现，在体细胞中众所周知的Dxz4分隔的巨型结构之前，Xist基因座上有一个具有边界的巨型结构。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution