Visible Light Photocatalyzed Norrish Type II Reaction of Acrylamides for the Synthesis of β‐Lactams

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-02-04 DOI:10.1002/adsc.202400976

Hao‐Yuan Li , Shen‐Zhen Zhang , Xiaoying Niu , Qing‐Yuan Meng , Xiu‐Long Yang

引用次数: 0

Abstract

Here, we present a strategy for the visible‐light‐catalyzed synthesis of β‐lactams based on the Norrish type II reaction. This protocol uses acetonitrile as solvent and commercially available photocatalyst to drive the reaction. Notably, various challenging substrate types reported in previous studies undergo conversion. DFT calculations further elucidate the reaction mechanism, while discussing the competitiveness between [2+2] cycloaddition and the Norrish II reaction.

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用可见光光催化丙烯酰胺的 Norrish II 型反应合成 β-内酰胺

在此，我们介绍一种基于 Norrish II 型反应的可见光催化合成 β-内酰胺的策略。该方案使用乙腈作为溶剂，并使用市售光催化剂来驱动反应。值得注意的是，以往研究中报道的各种具有挑战性的底物类型都发生了转化。DFT 计算进一步阐明了反应机理，同时讨论了 [2+2] 环加成反应和 Norrish II 反应之间的竞争性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.