Spatial mapping of primary and metastatic pancreatic tumor ecosystems

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2024-09-26 DOI:10.1038/s41588-024-01915-3

引用次数: 0

Abstract

This study presents a spatial transcriptomic analysis of matched primary tumors, liver metastases and lymph node metastases from patients with pancreatic ductal adenocarcinoma. Using a tumor ecosystem approach, we uncovered notable tumor microenvironmental heterogeneity and marked differences between primary and metastatic samples, providing key insights into metastatic pancreatic cancer.

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原发性和转移性胰腺肿瘤生态系统的空间分布图

本研究对胰腺导管腺癌患者的匹配原发肿瘤、肝转移灶和淋巴结转移灶进行了空间转录组学分析。利用肿瘤生态系统方法，我们发现了原发样本和转移样本之间显著的肿瘤微环境异质性和明显差异，为我们深入了解转移性胰腺癌提供了关键信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution