A material change for ultra-high precision force sensing

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2024-09-26 DOI:10.1038/s41377-024-01626-8

Christopher Perrella, Kishan Dholakia

引用次数: 0

Abstract

An original form of photonic force microscope has been developed. Operating with a trapped lanthanide-doped crystal of nanometric dimensions, a minimum detected force of the order of 110 aN and a force sensitivity down to 1.8 fN/\(\sqrt{{\rm{Hz}}}\) have been realised. This opens up new prospects for force sensing in the physical sciences.

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用于超高精度力传感的材料变化

一种新型光子力显微镜已经研制成功。通过使用纳米尺寸的掺杂镧系元素的受困晶体，实现了 110 aN 的最小检测力和低至 1.8 fN/\(\sqrt{\{rm{Hz}}) 的力灵敏度。这为物理科学中的力传感开辟了新的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.