Effects of Drug-Coated Balloons on Inflammatory Cytokines After Interventional Therapy for Coronary Artery Calcification

IF 1.6 3区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Jiaming Yu, Feng Zhu, Aqiang Yang, Zhi Wang, Chi Yuan, Guohua Xia, Wei Wang, Xuanwei Song, Zhengzheng Chen, Yinji Wu, Yihang Sun, Lingxiao Pan, Yongsheng Ke, Hegui Wang
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引用次数: 0

Abstract

Objective: To investigate the effects of a drug-coated balloon (DCB) on inflammatory cytokines in patients with coronary artery calcification (CAC) after interventional therapy.

Methods: This study included 58 patients with coronary heart disease who underwent coronary angiography (CAG) from October 2020 to September 2021. Patients were divided into CAC and non-CAC groups, and a DCB was used to intervene in the target lesions. Ten-milliliter preoperative and postoperative blood samples were drawn from the coronary lesions in both groups to detect the expression of serum interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and intercellular adhesion molecule-1 (ICAM-1). All patients were subjected to a 6-month follow-up to observe the incidence of major adverse cardiac events (MACEs).

Results: No significant differences in baseline clinical data were found between the groups. Serum IL-6, TNF-α, and ICAM-1 expressions in coronary blood samples immediately before DCB were not significantly different from those after DCB in all patients. After DCB, serum TNF-α expression in the CAC group was significantly lower than that in the non-CAC group (p < 0.05). In contrast, no significant difference in serum IL-6 and ICAM-1 expression was found between the groups. During the 6-month follow-up, no significant difference in the incidence of MACE was found between both groups.

Conclusions: DCB reduced the expression of inflammatory cytokine TNF-α in CAC, which may be one of the key mechanisms underlying the treatment of CAC by DCB.

冠状动脉钙化介入治疗后药物涂层球囊对炎性细胞因子的影响
目的研究药物涂层球囊(DCB)对冠状动脉钙化(CAC)患者介入治疗后炎症细胞因子的影响。 研究方法本研究纳入了 2020 年 10 月至 2021 年 9 月期间接受冠状动脉造影术(CAG)的 58 名冠心病患者。患者被分为 CAC 组和非 CAC 组,并使用 DCB 介入靶病变。两组患者术前和术后均从冠状动脉病变处抽取10毫升血液样本,检测血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和细胞间粘附分子-1(ICAM-1)的表达。对所有患者进行为期 6 个月的随访,观察主要心脏不良事件(MACE)的发生率。 结果两组患者的基线临床数据无明显差异。所有患者冠状动脉造影术前血清IL-6、TNF-α和ICAM-1的表达与造影术后无明显差异。DCB 后,CAC 组血清 TNF-α 的表达明显低于非 CAC 组(p < 0.05)。相比之下,两组患者血清中 IL-6 和 ICAM-1 的表达没有明显差异。在 6 个月的随访中,两组患者的 MACE 发生率无明显差异。 结论DCB降低了CAC中炎症细胞因子TNF-α的表达,这可能是DCB治疗CAC的关键机制之一。
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来源期刊
Journal of interventional cardiology
Journal of interventional cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.80
自引率
0.00%
发文量
81
审稿时长
6-12 weeks
期刊介绍: Journal of Interventional Cardiology is a peer-reviewed, Open Access journal that provides a forum for cardiologists determined to stay current in the diagnosis, investigation, and management of patients with cardiovascular disease and its associated complications. The journal publishes original research articles, review articles, and clinical studies focusing on new procedures and techniques in all major subject areas in the field, including: Acute coronary syndrome Coronary disease Congenital heart diseases Myocardial infarction Peripheral arterial disease Valvular heart disease Cardiac hemodynamics and physiology Haemostasis and thrombosis
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