Molecular mechanisms and therapeutic effects of natural products in inflammatory bowel disease

Abstract

The etiology of inflammatory bowel disease (IBD) is intricately influenced by the complex interplay of environmental factors, alterations in gut flora, genetic predisposition, and modifications in the immune system. The global incidence of IBD has surged significantly in recent decades, with reports of nutritional deficiencies among affected individuals. Nutritional factors can exacerbate intestinal inflammation by disrupting immune responses, modifying gut barrier integrity, impacting the mucosal layer and fostering microbial imbalances. As a result, modifications to dietary intake and nutritional supplementation are regarded as additional components of common IBD treatment strategies. This review delves into the properties, cellular pathways and the research outcomes examining the efficacy of dietary nutritional supplements like curcumin, resveratrol, selenium, quercetin, and vitamin D as supportive therapy for IBD patients.