Photocatalytic Oxidation of α‐Substituted Amines to Lactams/Amides

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-02-04 DOI:10.1002/adsc.202400871

Manish Kumar , Pawan Kumar , Utpal Das

引用次数: 0

Abstract

We, herein, report a base free, photocatalytic decyanation of α‐aminonitriles. A range of amides and lactams were obtained in 52–95% yields. Control experiments indicate O₂ as an amide/lactam oxygen source and the reaction (lactam formation) follows radical pathway via dioxetanimine species. This methodology also applied for α‐ester/aldehyde substituted pyrrolidines in the presence of a base, probably via decarboxylation pathway.

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光催化 α-取代胺氧化成内酰胺/酰胺

我们在此报告了一种无碱光催化α-氨基硝酰胺脱氰反应。我们以 52-95% 的产率获得了一系列酰胺和内酰胺。对照实验表明，O2 是酰胺/内酰胺的氧源，反应（内酰胺的形成）通过二氧乙脒物种遵循自由基途径。这种方法也适用于存在碱的α-酯/醛取代的吡咯烷，可能是通过脱羧途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.