Light-Armed Nitric Oxide-Releasing Micromotor In Vivo

IF 11.3 1区化学 Q1 CHEMISTRY, PHYSICAL

ACS Catalysis Pub Date : 2024-09-25 DOI:10.1021/acs.nanolett.4c03120

Tiange Zhang, Haojiang Ren, Haifeng Qin, Xiaoshuai Liu, Baojun Li, Xianchuang Zheng

引用次数: 0

Abstract

The delivery of NO at a high spatiotemporal precision is important but still challenging for existing NO-releasing platforms due to the lack of precise motion control and limited biomedical functions. In this work, we propose an alternative strategy for developing the light-armed nitric oxide-releasing micromotor (LaNorM), in which a main light beam was employed to navigate the microparticle and stimulate NO release and an auxiliary light beam was used to cooperate with the released NO to act as a remotely controlled scalpel for cell separation. Benefiting from the advantages of fully controlled locomotion, photostimulated NO release, and microsurgery ability at the single-cell level, the proposed LaNorM could enable a series of biomedical applications in vivo, including the separation of flowing emboli, selective removal of a specific thrombus, and inhibition of thrombus growth, which may provide new insight into the precise delivery of NO and the treatment of cardiovascular diseases.

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体内光臂一氧化氮释放微马达

高时空精度地释放一氧化氮非常重要，但由于缺乏精确的运动控制和有限的生物医学功能，现有的一氧化氮释放平台仍面临挑战。在这项工作中，我们提出了开发光臂一氧化氮释放微马达（LaNorM）的另一种策略，即利用主光束导航微粒子并刺激一氧化氮释放，同时利用辅助光束与释放的一氧化氮配合，充当细胞分离的遥控手术刀。由于具有完全可控运动、光刺激 NO 释放和单细胞水平显微手术能力等优点，拟议的 LaNorM 可在体内实现一系列生物医学应用，包括分离流动的栓子、选择性清除特定血栓和抑制血栓生长，从而为精确输送 NO 和治疗心血管疾病提供新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.