Exploring social determinants of health on chemotherapy-induced peripheral neuropathy severity in ovarian cancer: An integrative review

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY
Chisom O. Odii, David E. Vance, Fiona B. A. T. Agbor, Amanda Jenkins, Ellen M. Lavoie Smith
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引用次数: 0

Abstract

Ovarian cancer remains a significant public health concern for women despite advancements in cancer management. Despite comprising only 2.5 % of cancers in women, ovarian cancer ranks as the fifth leading cause of cancer-related deaths among women, with patients frequently receiving late diagnoses. Chemotherapy, a primary treatment, frequently causes chemotherapy-induced peripheral neuropathy (CIPN), affecting over 60 % of patients and leading to severe sensory, motor, and autonomic nerve impairments. This often necessitates dosage reduction or discontinuation of treatment, thereby increasing mortality. While CIPN’s impact on patients is well-documented, there is a paucity of knowledge of how structural and intermediary social determinants of health factors (SDOH), such as socioeconomic and political context, material circumstances such as living and walking conditions, area deprivation, and food availability, affect CIPN severity. The aim of this article was to explore the association between various SDOH and CIPN severity in ovarian cancer, identifying potential research gaps and future research directions. This article seeks to inform targeted interventions to mitigate CIPN’s impact by elucidating these associations.
探讨健康的社会决定因素对卵巢癌化疗所致周围神经病变严重程度的影响:综合综述
尽管在癌症治疗方面取得了进步,但卵巢癌仍然是妇女的一个重大公共健康问题。尽管卵巢癌只占女性癌症的 2.5%,但它却是导致女性癌症相关死亡的第五大原因,而且患者经常被晚期诊断。化疗作为一种主要治疗方法,经常会引起化疗诱发的周围神经病变(CIPN),影响超过 60% 的患者,导致严重的感觉、运动和自主神经损伤。这往往需要减少剂量或中断治疗,从而增加死亡率。虽然 CIPN 对患者的影响已得到充分证实,但对于结构性和中间性健康社会决定因素 (SDOH) 如社会经济和政治环境、物质条件(如居住和行走条件)、地区贫困和食物供应等如何影响 CIPN 的严重程度却知之甚少。本文旨在探讨各种 SDOH 与卵巢癌 CIPN 严重程度之间的关联,找出潜在的研究空白和未来的研究方向。本文旨在通过阐明这些关联,为有针对性的干预措施提供信息,以减轻 CIPN 的影响。
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来源期刊
Gynecologic Oncology Reports
Gynecologic Oncology Reports OBSTETRICS & GYNECOLOGY-
CiteScore
2.00
自引率
0.00%
发文量
183
审稿时长
41 days
期刊介绍: Gynecologic Oncology Reports is an online-only, open access journal devoted to the rapid publication of narrative review articles, survey articles, case reports, case series, letters to the editor regarding previously published manuscripts and other short communications in the field of gynecologic oncology. The journal will consider papers that concern tumors of the female reproductive tract, with originality, quality, and clarity the chief criteria of acceptance.
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