Exploring quorum sensing for inducing bioactives overproduction in the dinoflagellate microalga Amphidinium carterae

IF 4.6 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Algal Research-Biomass Biofuels and Bioproducts Pub Date : 2024-09-19 DOI:10.1016/j.algal.2024.103719

S. Kichouh-Aiadi, J.J. Gallardo-Rodríguez, L. López-Rosales, M.C. Cerón-García, F. García-Camacho, A. Sánchez-Mirón

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Abstract

The dinoflagellate Amphidinium carterae is a promising source of unique bioactive compounds with potential applications in diverse industries. Abiotic strategies for increasing bioactive cell quota have been preferred for cost-effectiveness, controllability, and existing knowledge. The supernatants of Heterosigma akashiwo and Pavlova sp. enhanced haemolytic activity of A. carterae by 2.3 times and improved its final biomass by 10 % when added to the growth medium. Prymnesium parvum supernatant increased the total lipid content of A. carterae by 50 %, while Pleurochrysis roscoffensis supernatant boosted its total carotenoid content by 40 %. This study demonstrated a rapid screening strategy for evaluating growth responses and highlights the potential of using allelopathic strategies to enhance bioactive metabolite production. Utilizing supernatants for the formulation of growth media fosters a circular economy by repurposing resources, minimizing waste, and promoting sustainability in the microalgal biotechnological industry.

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探索通过定量感应诱导甲藻中生物活性物质的过量生产

甲壳双鞭毛藻（Amphidinium carterae）是一种前景广阔的独特生物活性化合物来源，具有在不同行业应用的潜力。由于成本效益、可控性和现有知识，增加生物活性细胞配额的非生物策略已成为首选。Heterosigma akashiwo 和 Pavlova sp.的上清液加入生长培养基后，可将 A. carterae 的溶血活性提高 2.3 倍，并将其最终生物量提高 10%。Prymnesium parvum 上清液可将 A. carterae 的总脂质含量提高 50%，而 Pleurochrysis roscoffensis 上清液可将其总类胡萝卜素含量提高 40%。这项研究展示了一种评估生长反应的快速筛选策略，并强调了利用等位策略提高生物活性代谢物产量的潜力。利用上清液配制生长介质，可以重新利用资源，最大限度地减少浪费，促进微藻生物技术产业的可持续发展，从而推动循环经济的发展。

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来源期刊

Algal Research-Biomass Biofuels and Bioproducts BIOTECHNOLOGY & APPLIED MICROBIOLOGY-

CiteScore

9.40

自引率

7.80%

发文量

332

期刊介绍： Algal Research is an international phycology journal covering all areas of emerging technologies in algae biology, biomass production, cultivation, harvesting, extraction, bioproducts, biorefinery, engineering, and econometrics. Algae is defined to include cyanobacteria, microalgae, and protists and symbionts of interest in biotechnology. The journal publishes original research and reviews for the following scope: algal biology, including but not exclusive to: phylogeny, biodiversity, molecular traits, metabolic regulation, and genetic engineering, algal cultivation, e.g. phototrophic systems, heterotrophic systems, and mixotrophic systems, algal harvesting and extraction systems, biotechnology to convert algal biomass and components into biofuels and bioproducts, e.g., nutraceuticals, pharmaceuticals, animal feed, plastics, etc. algal products and their economic assessment