High levels of the health-relevant antioxidant selenoneine identified in the edible mushroom Boletus edulis

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2024-09-20 DOI:10.1016/j.jtemb.2024.127536

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引用次数: 0

Abstract

Background

Selenoneine, the selenium analogue of the sulfur antioxidant ergothioneine, has been ascribed a multitude of beneficial health effects. Natural nutritional sources for this selenium species are, hence, of high interest. So far marine fish is the only significant selenoneine source consumed by larger parts of the population worldwide.

Methods

As selenoneine and ergothioneine share their biosynthetic pathways and transport mechanisms and the popular edible porcini mushroom Boletus edulis is rich in ergothioneine and selenium, we conducted a preliminary study investigating a composite sample of two specimens of B. edulis for their selenoneine content by HPLC coupled to elemental and molecular mass spectrometry after aqueous extraction.

Results

Selenium speciation analysis by HPLC-ICPMS revealed that ca. 860 µg Se kg⁻¹ wet mass (81 % of the total Se) co-eluted with a selenoneine standard and a minor selenium species with Se-methylselenoneine. The presence of selenoneine was rigorously proven by HPLC-ESI-Orbitrap MS. The selenoneine content of the investigated specimens of B. edulis was higher than that of commonly consumed muscle of marine fish species, like tuna or mackerel.

Conclusion

This is the first report of a terrestrial food source containing significant selenoneine levels. Our results suggest that B. edulis might represent a complementary natural supply with this health-relevant selenium species for humans.

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在食用菌牛肝菌中发现大量与健康相关的抗氧化剂硒酮

背景硒是硫抗氧化剂麦角硫因的硒类似物，具有多种有益健康的作用。因此，这种硒的天然营养来源备受关注。由于硒酮和麦角硫因具有相同的生物合成途径和转运机制，而广受欢迎的食用牛肝菌富含麦角硫因和硒，因此我们进行了一项初步研究，调查了两种牛肝菌标本的复合样本中硒酮和麦角硫因的含量。结果通过 HPLC-ICPMS 进行的硒标样分析表明，约 860 µg Se kg-1 湿重的牛肝菌中含有硒。860 µg Se kg-1 湿重（占总硒量的 81%）与硒酮标准品和一个次要硒物种 Se-methylselenoneine 共同沉淀。HPLC-ESI-Orbitrap MS 严格证明了硒酮的存在。被调查的江豚标本的硒酮含量高于通常食用的金枪鱼或鲭鱼等海洋鱼类的肌肉。我们的研究结果表明，B. edulis 可能是与人类健康相关的硒物种的天然补充供应。

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.