{"title":"Fine-tuning extracellular fluid viscosity enhances gene delivery","authors":"Ajay S. Thatte, Dongyoon Kim, Michael J. Mitchell","doi":"10.1038/s44286-024-00118-1","DOIUrl":null,"url":null,"abstract":"Successful gene delivery is predicated on the effective cellular uptake of encapsulated nucleic acid cargo. Now, a study identifies extracellular fluid viscosity as a key factor that governs gene delivery via non-viral and viral vectors across a range of cell types.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"1 9","pages":"559-560"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Chemical Engineering","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44286-024-00118-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Successful gene delivery is predicated on the effective cellular uptake of encapsulated nucleic acid cargo. Now, a study identifies extracellular fluid viscosity as a key factor that governs gene delivery via non-viral and viral vectors across a range of cell types.
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