A novel thiourea-based fluorescent turn-on sensor for rapidly detecting hypochlorite through a desulfurization reaction

IF 1.7 4区 化学
Boeun Choi, Soyeon Kim, Cheal Kim
{"title":"A novel thiourea-based fluorescent turn-on sensor for rapidly detecting hypochlorite through a desulfurization reaction","authors":"Boeun Choi,&nbsp;Soyeon Kim,&nbsp;Cheal Kim","doi":"10.1002/bkcs.12897","DOIUrl":null,"url":null,"abstract":"<p>Excess hypochlorite (ClO<sup>−</sup>) is harmful to living organisms and can cause various oxidative diseases in the human body. Owing to the toxicity of ClO<sup>−</sup>, the development of efficient fluorescence sensors to track ClO<sup>−</sup> is necessary. In this work, we report a novel thiourea-based fluorescent turn-on sensor 1-(9-ethyl-9<i>H</i>-carbazol-3-yl)-3-(naphthalen-1-yl)thiourea (<b>ECNT</b>) for recognizing ClO<sup>−</sup>. <b>ECNT</b> can detect ClO<sup>−</sup> with high selectivity, relatively low interference with other analytes, and a significantly fast response time (&lt;1 s) through a desulfurization reaction. The detection limit of <b>ECNT</b> for ClO<sup>−</sup> is calculated as 5.59 μM. Of note, <b>ECNT</b> is a chemosensor that reacts the fastest with ClO<sup>−</sup> among the reported thiourea-based fluorescence turn-on sensors for detecting ClO<sup>−</sup>. The response mechanism of <b>ECNT</b> to ClO<sup>−</sup> is demonstrated through <sup>1</sup>H NMR titration, ESI mass, and density functional theory calculations.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of the Korean Chemical Society","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bkcs.12897","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Excess hypochlorite (ClO) is harmful to living organisms and can cause various oxidative diseases in the human body. Owing to the toxicity of ClO, the development of efficient fluorescence sensors to track ClO is necessary. In this work, we report a novel thiourea-based fluorescent turn-on sensor 1-(9-ethyl-9H-carbazol-3-yl)-3-(naphthalen-1-yl)thiourea (ECNT) for recognizing ClO. ECNT can detect ClO with high selectivity, relatively low interference with other analytes, and a significantly fast response time (<1 s) through a desulfurization reaction. The detection limit of ECNT for ClO is calculated as 5.59 μM. Of note, ECNT is a chemosensor that reacts the fastest with ClO among the reported thiourea-based fluorescence turn-on sensors for detecting ClO. The response mechanism of ECNT to ClO is demonstrated through 1H NMR titration, ESI mass, and density functional theory calculations.

通过脱硫反应快速检测次氯酸盐的新型硫脲基荧光导通传感器
过量的次氯酸盐(ClO-)对生物体有害,可导致人体各种氧化性疾病。由于 ClO- 的毒性,有必要开发高效的荧光传感器来跟踪 ClO-。在这项工作中,我们报告了一种新型的基于硫脲的荧光开启传感器 1-(9-乙基-9H-咔唑-3-基)-3-(萘-1-基)硫脲(ECNT),用于识别 ClO-。ECNT 可通过脱硫反应检测 ClO-,具有高选择性,对其他分析物的干扰相对较低,且响应时间极短(1 秒)。根据计算,ECNT 对 ClO- 的检测限为 5.59 μM。值得注意的是,在已报道的基于硫脲的检测 ClO- 的荧光开启传感器中,ECNT 是与 ClO- 反应最快的化学传感器。通过 1H NMR 滴定、ESI 质量和密度泛函理论计算,证明了 ECNT 对 ClO- 的反应机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Bulletin of the Korean Chemical Society
Bulletin of the Korean Chemical Society Chemistry-General Chemistry
自引率
23.50%
发文量
182
期刊介绍: The Bulletin of the Korean Chemical Society is an official research journal of the Korean Chemical Society. It was founded in 1980 and reaches out to the chemical community worldwide. It is strictly peer-reviewed and welcomes Accounts, Communications, Articles, and Notes written in English. The scope of the journal covers all major areas of chemistry: analytical chemistry, electrochemistry, industrial chemistry, inorganic chemistry, life-science chemistry, macromolecular chemistry, organic synthesis, non-synthetic organic chemistry, physical chemistry, and materials chemistry.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信