{"title":"A novel thiourea-based fluorescent turn-on sensor for rapidly detecting hypochlorite through a desulfurization reaction","authors":"Boeun Choi, Soyeon Kim, Cheal Kim","doi":"10.1002/bkcs.12897","DOIUrl":null,"url":null,"abstract":"<p>Excess hypochlorite (ClO<sup>−</sup>) is harmful to living organisms and can cause various oxidative diseases in the human body. Owing to the toxicity of ClO<sup>−</sup>, the development of efficient fluorescence sensors to track ClO<sup>−</sup> is necessary. In this work, we report a novel thiourea-based fluorescent turn-on sensor 1-(9-ethyl-9<i>H</i>-carbazol-3-yl)-3-(naphthalen-1-yl)thiourea (<b>ECNT</b>) for recognizing ClO<sup>−</sup>. <b>ECNT</b> can detect ClO<sup>−</sup> with high selectivity, relatively low interference with other analytes, and a significantly fast response time (<1 s) through a desulfurization reaction. The detection limit of <b>ECNT</b> for ClO<sup>−</sup> is calculated as 5.59 μM. Of note, <b>ECNT</b> is a chemosensor that reacts the fastest with ClO<sup>−</sup> among the reported thiourea-based fluorescence turn-on sensors for detecting ClO<sup>−</sup>. The response mechanism of <b>ECNT</b> to ClO<sup>−</sup> is demonstrated through <sup>1</sup>H NMR titration, ESI mass, and density functional theory calculations.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of the Korean Chemical Society","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bkcs.12897","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Excess hypochlorite (ClO−) is harmful to living organisms and can cause various oxidative diseases in the human body. Owing to the toxicity of ClO−, the development of efficient fluorescence sensors to track ClO− is necessary. In this work, we report a novel thiourea-based fluorescent turn-on sensor 1-(9-ethyl-9H-carbazol-3-yl)-3-(naphthalen-1-yl)thiourea (ECNT) for recognizing ClO−. ECNT can detect ClO− with high selectivity, relatively low interference with other analytes, and a significantly fast response time (<1 s) through a desulfurization reaction. The detection limit of ECNT for ClO− is calculated as 5.59 μM. Of note, ECNT is a chemosensor that reacts the fastest with ClO− among the reported thiourea-based fluorescence turn-on sensors for detecting ClO−. The response mechanism of ECNT to ClO− is demonstrated through 1H NMR titration, ESI mass, and density functional theory calculations.
期刊介绍:
The Bulletin of the Korean Chemical Society is an official research journal of the Korean Chemical Society. It was founded in 1980 and reaches out to the chemical community worldwide. It is strictly peer-reviewed and welcomes Accounts, Communications, Articles, and Notes written in English. The scope of the journal covers all major areas of chemistry: analytical chemistry, electrochemistry, industrial chemistry, inorganic chemistry, life-science chemistry, macromolecular chemistry, organic synthesis, non-synthetic organic chemistry, physical chemistry, and materials chemistry.