Continuous biomanufacturing for sustainable bioeconomy applications

Ana G. Del Hierro , Juan A. Moreno-Cid , Eoin Casey
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Abstract

The bioeconomy provides an alternative to non-renewable or fossil-based products. Biomanufacturing is emerging as a sustainable platform for the production of a wide range of value-added products, including chemicals and biodegradable materials. At present, the biotechnology industry is dominated by batch and fed-batch processes and there is increasing interest in continuous biomanufacturing (CBM) as an alternative to reduce capital and operating costs. However, CBM faces adoption challenges due to perceived operational complexities. This review critically evaluates the state-of-the-art in CBM, examining its benefits, limitations, and successful industrial applications across key sectors. Transitioning from batch to continuous processes can enhance productivity and reduce environmental impacts, making CBM a cornerstone technology for a sustainable bioeconomy.

Abstract Image

可持续生物经济应用的连续生物制造
生物经济为不可再生或化石产品提供了替代品。生物制造正在成为生产各种增值产品(包括化学品和可生物降解材料)的可持续平台。目前,生物技术产业主要采用间歇和喂料间歇工艺,而人们对连续生物制造(CBM)作为降低资本和运营成本的替代方法越来越感兴趣。然而,由于操作的复杂性,CBM 的采用面临挑战。本综述对 CBM 的最新进展进行了严格评估,研究了 CBM 的优势、局限性以及在关键领域的成功工业应用。从间歇式工艺过渡到连续式工艺可以提高生产率并减少对环境的影响,从而使煤层气技术成为可持续生物经济的基石技术。
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