Acute cardiorenal dysfunctions induced by isoprenaline in Wistar rats: Mitigating potential of Juglans regia hull extract

Pawan Kumar Verma , Priyanka Sharma , Shilpa Sood , Sheen Tukra , Nrip K. Pankaj , Gholamreza Abdi , Zuhaib F. Bhat
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Abstract

The present study aimed to determine the attenuating properties of Juglans regia hull extract (JRHE) in mitigating isoprenaline (ISO) induced cardiorenal dysfunctions in Wistar rats. Thirty adult Wistar rats were randomly allocated to five groups with six animals in each group. Group I served as control; group II animals were administered ISO and group III received JRHE alone whereas group IV and V received JRHE and quercetin along with ISO, respectively. Administration of ISO in rats induced cardiac and renal tissue damage as reflected by significantly (p < 0.05) increased plasma activities of creatine kinase-myocardial band, lactate dehydrogenase, acetylcholinesterase, arylesterase, blood urea nitrogen, creatinine along with altered antioxidant biomarkers viz. total antioxidant status, total thiols, superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and increased (p < 0.05) lipid and protein peroxidation in cardiac and renal tissues. Histopathological findings corroborated that ISO has inflicted significant damage on cardiac and renal tissues. Repeated administration of JRHE significantly (p < 0.05) reduced the severity of ISO-induced alterations in blood, cardiac and renal biomarkers. In addition to restoring the levels of altered cardio-renal antioxidant enzymes, JRHE also ameliorated histopathological lesions in cardiac and renal tissues in ISO-treated rats.
异丙肾上腺素诱发 Wistar 大鼠急性心肾功能障碍:胡桃壳提取物的缓解潜力
本研究旨在确定胡桃壳提取物(JRHE)在减轻异丙肾上腺素(ISO)诱导的 Wistar 大鼠心肾功能障碍方面的减弱特性。将 30 只成年 Wistar 大鼠随机分为五组,每组六只。I 组为对照组;II 组大鼠服用 ISO,III 组大鼠仅服用 JRHE,而 IV 组和 V 组大鼠在服用 ISO 的同时分别服用 JRHE 和槲皮素。给大鼠注射 ISO 会诱发心脏和肾脏组织损伤,表现为血浆中肌酸激酶-心肌带、乳酸脱氢酶、乙酰胆碱酯酶、芳香族酯酶、血尿素氮、肌酐的活性显著增加(p < 0.05),以及抗氧化生物标志物的改变,即总抗氧化状态、总抗氧化状态、总抗氧化状态、总抗氧化状态、总抗氧化状态、总抗氧化状态、总抗氧化状态、总抗氧化状态、总抗氧化状态、总抗氧化状态、总抗氧化状态、总抗氧化状态、总抗氧化状态、总抗氧化状态、总抗氧化状态。心脏和肾脏组织中的总抗氧化状态、总硫醇、超氧化物歧化酶、过氧化氢酶、谷胱甘肽还原酶、谷胱甘肽过氧化物酶以及脂质和蛋白质过氧化物增加(p < 0.05)。组织病理学研究结果证实,ISO 对心脏和肾脏组织造成了严重损害。重复给药 JRHE 能明显(p < 0.05)减轻 ISO 引起的血液、心脏和肾脏生物标志物变化的严重程度。除了恢复心肾抗氧化酶的水平变化外,JRHE 还能改善 ISO 处理大鼠心脏和肾脏组织的组织病理学病变。
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来源期刊
Food chemistry advances
Food chemistry advances Analytical Chemistry, Organic Chemistry, Chemistry (General), Molecular Biology
CiteScore
1.90
自引率
0.00%
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0
审稿时长
99 days
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