Genetic predisposition to vitamin D deficiency in Indian athletes: Role of CYP2R1 rs10741657 variant

IF 1 Q4 GENETICS & HEREDITY
Kavanashri N.M. , Keren Harish Tiwari , Sandeep Kumar Kotturu , Dinesh Yadav D.M. , Sudip Ghosh , Venkata Ramana Yagnambhatt
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Abstract

Vitamin D deficiency can negatively impact the health and training efficiency of athletes. The rs10741657(G) allele in CYP2R1 gene has been associated with lower vitamin D status, potentially contributing to vitamin D deficiency observed across various populations, including Indians. This study aimed to investigate whether the CYP2R1 (rs10741657) polymorphism is contributing to the vitamin D status among Indian athletes. Blood samples were collected from 92 Indian elite and sub-elite athletes participating in weightlifting (29), badminton (32), athletics (14), and rowing (17) for laboratory analysis. PCR-RFLP of the CYP2R1 (rs10741657) SNP was performed, and vitamin D levels were measured. Statistical analysis was done to assess the association between genotype and vitamin D status. Vitamin D levels were comparable between genders but differed across sports, with indoor athletes, especially badminton players having higher levels. The AA genotype was associated with higher vitamin D levels compared to the GG and AG genotypes. Vitamin D deficiency is highly prevalent among the athletes studied. This deficiency may be due to the higher prevalence of the alternate allele (G) of CYP2R1 polymorphism, suggesting that genetic predisposition plays a key role in determining the vitamin D status of athletes.
印度运动员维生素 D 缺乏的遗传易感性:CYP2R1 rs10741657 变异的作用
维生素 D 缺乏会对运动员的健康和训练效率产生负面影响。CYP2R1基因中的rs10741657(G)等位基因与较低的维生素D状态有关,可能是包括印度人在内的不同人群维生素D缺乏的原因之一。本研究旨在调查 CYP2R1(rs10741657)多态性是否与印度运动员的维生素 D 状态有关。研究人员采集了 92 名参加举重(29 人)、羽毛球(32 人)、田径(14 人)和赛艇(17 人)的印度精英和亚精英运动员的血样进行实验室分析。对 CYP2R1 (rs10741657) SNP 进行了 PCR-RFLP,并测量了维生素 D 水平。统计分析评估了基因型与维生素 D 状态之间的关联。不同性别之间的维生素 D 水平相当,但不同运动项目之间存在差异,室内运动员,尤其是羽毛球运动员的维生素 D 水平更高。与 GG 和 AG 基因型相比,AA 基因型的维生素 D 水平更高。在所研究的运动员中,维生素 D 缺乏症非常普遍。这种缺乏可能是由于 CYP2R1 多态性的另一等位基因(G)的流行率较高,这表明遗传易感性在决定运动员的维生素 D 状态方面起着关键作用。
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来源期刊
Gene Reports
Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
3.30
自引率
7.70%
发文量
246
审稿时长
49 days
期刊介绍: Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.
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