3D-printed magnesium-doped micro-nano bioactive glass composite scaffolds repair critical bone defects by promoting osteogenesis, angiogenesis, and immunomodulation.

Biomedical materials (Bristol, England) Pub Date : 2024-10-16 DOI:10.1088/1748-605X/ad7e8e

Kun Dai, Fujian Zhao, Wen Zhang, Dafu Chen, Fei Hang, Xuenong Zou, Xiaofeng Chen

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Abstract

Magnesium ions play an important immune-regulatory role during bone repair. For this study, we prepared micro-nano bioactive glass (MNBG) containing magnesium, which can release magnesium, silicon, and calcium ions and has a positive impact on osteogenic differentiation and vascular regeneration. In this study, MgMNBG was compounded and combined with poly(lactic-co-glycolic acid (PLGA) and polycaprolactone (PCL) for 3D printing. Afterwards, the physicochemical properties and bone repair performance of the scaffolds were evaluated throughin vitroandin vivoexperiments. We also investigated the effects of MgMNBG on osteogenic differentiation, immune regulation, and vascular regeneration. The results showed that MgMNBG can inhibit inflammation and promote osteogenesis and angiogenesis by regulating macrophages. PLGA/PCL/MgMNBG scaffolds have good osteogenic and angiogenic effects, and the composite scaffolds have excellent bone repair performance and potential application value.

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三维打印掺镁微纳米生物活性玻璃复合支架通过促进骨生成、血管生成和免疫调节修复关键性骨缺损。

镁离子在骨修复过程中发挥着重要的免疫调节作用。在这项研究中，我们制备了含镁的微纳米生物活性玻璃，它能释放镁、硅和钙离子，对成骨分化和血管再生有积极影响。在这项研究中，MgMNBG 与 PLGA 和 PCL 复合并进行 3D 打印。随后，通过体外和体内实验评估了支架的理化性质和骨修复性能。我们还研究了 MgMNBG 对成骨分化、免疫调节和血管再生的影响。结果表明，MgMNBG 可抑制炎症，并通过调节巨噬细胞促进成骨和血管生成。PLGA/PCL/MgMNBG支架具有良好的成骨和血管生成作用，复合支架具有优异的骨修复性能和潜在的应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomedical materials (Bristol, England)

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