The role of C-reactive protein as a risk marker of postoperative delirium in older hip fracture patients: a prospective cohort study.

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

European Geriatric Medicine Pub Date : 2024-12-01 Epub Date: 2024-09-24 DOI:10.1007/s41999-024-01046-2

Lucía Lozano-Vicario, Ángel Javier Muñoz-Vázquez, Bernardo Abel Cedeno-Veloz, Román Romero-Ortuno, Arkaitz Galbete, Joaquín Fernández-Irigoyen, Enrique Santamaría, Fabricio Zambom-Ferraresi, José Ramón Ortiz-Gómez, Ángel Manuel Hidalgo-Ovejero, Nicolás Martínez-Velilla

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引用次数: 0

Abstract

Purpose: Postoperative delirium (POD) is a common and serious neuropsychiatric syndrome that leads to higher morbidity and mortality. We investigated the association between serum C-reactive protein (CRP) and the occurrence of POD in older hip fracture patients, and whether CRP predicted POD better than a clinical model.

Methods: Patients aged ≥ 75 years admitted for surgical repair of an acute hip fracture were recruited. We compared serum CRP levels between patients with and without POD.

Results: Sixty patients were included, of whom 21 (35%) developed POD. Serum CRP levels were significantly higher in patients who developed delirium (p = 0.011). In a multiple regression model including clinical variables and CRP, cognitive impairment (p = 0.003) and infection (p = 0.001) were the best predictors of POD.

Conclusions: Although higher levels of serum CRP were significantly associated with POD in older hip fracture patients, pre-existing cognitive impairment and infections were the most important risk factors for POD.

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C 反应蛋白作为老年髋部骨折患者术后谵妄风险标志物的作用：一项前瞻性队列研究。

目的：术后谵妄（POD）是一种常见的严重神经精神综合征，会导致较高的发病率和死亡率。我们研究了老年髋部骨折患者血清 C 反应蛋白（CRP）与 POD 发生之间的关系，以及 CRP 预测 POD 的效果是否优于临床模型：方法：招募年龄≥ 75 岁的急性髋部骨折手术修复患者。我们比较了有 POD 和无 POD 患者的血清 CRP 水平：结果：共纳入 60 例患者，其中 21 例（35%）出现 POD。出现谵妄的患者血清 CRP 水平明显更高（p = 0.011）。在包括临床变量和 CRP 的多元回归模型中，认知障碍（p = 0.003）和感染（p = 0.001）是预测 POD 的最佳指标：结论：虽然血清 CRP 水平较高与老年髋部骨折患者的 POD 显著相关，但已有的认知障碍和感染是 POD 的最重要风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Geriatric Medicine GERIATRICS & GERONTOLOGY-

CiteScore

6.70

自引率

2.60%

发文量

114

审稿时长

6-12 weeks

期刊介绍： European Geriatric Medicine is the official journal of the European Geriatric Medicine Society (EUGMS). Launched in 2010, this journal aims to publish the highest quality material, both scientific and clinical, on all aspects of Geriatric Medicine. The EUGMS is interested in the promotion of Geriatric Medicine in any setting (acute or subacute care, rehabilitation, nursing homes, primary care, fall clinics, ambulatory assessment, dementia clinics..), and also in functionality in old age, comprehensive geriatric assessment, geriatric syndromes, geriatric education, old age psychiatry, models of geriatric care in health services, and quality assurance.