A useful cognitive motor dual task paradigm in prodromal and manifest Huntington’s disease

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2024-09-11 DOI:10.1016/j.parkreldis.2024.107119

Emma Churchill , Shelby Hughes , Andrew Hall , Braden Culbert , Daniel J. Goble , Jody Corey-Bloom , Paul E. Gilbert

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引用次数: 0

Abstract

Introduction

Individuals with Huntington's disease (HD) experience increased difficulty with balance throughout disease progression. Adding a simultaneous cognitive task to a balance assessment, referred to as a dual task (DT) paradigm, may have a deleterious effect on balance, which can be expressed in terms of a Dual Task Cost (DTC), relative to a single task (ST) condition. The aim of this study is to explore whether a cognitive-motor DT paradigm uncovers balance deficits in prodromal (Pro-HD) and manifest HD, compared to healthy adults (HA).

Methods

Balance under ST and DT conditions was examined using the BTracks Balance Plate and Balance software in 30 individuals with HD, 17 individuals with Pro-HD, and 20 HA. During the DT condition, participants were simultaneously administered a version of the Paced Auditory Serial Addition Test (PASAT). DTC is calculated as the relative ratio of ST to DT, controlling for ST performance: DTC= (ST − DT)/ST x100.

Results

The HA group performed significantly better than the HD group on both the ST and DT conditions (p < 0.01), while balance scores between the HA and the Pro-HD groups were not significantly different. The DTC scores, however, were significantly better in the HA compared to both the HD (p < 0.001) and Pro-HD (p < 0.05) groups.

Conclusion

Our findings indicate that the addition of a cognitive task interferes with participant's balance, reflecting real-life performance, and may have additional value for estimating transition to manifest disease, appraising fall risk, or serving as a valid outcome measure in observational and interventional trials in HD.

查看原文本刊更多论文

前驱期和显现期亨廷顿症的有用认知运动双重任务范例。

导言：亨廷顿氏病（HD）患者在病情发展过程中会越来越难以保持平衡。相对于单一任务（ST）条件，在平衡评估中同时添加认知任务（称为双重任务（DT）范式）可能会对平衡产生有害影响，这种影响可以用双重任务成本（DTC）来表示。本研究旨在探讨认知运动DT范式是否能发现前驱期（Pro-HD）和显性HD与健康成人（HA）相比存在的平衡缺陷：方法：使用 BTracks 平衡板和平衡软件，对 30 名 HD 患者、17 名 Pro-HD 患者和 20 名 HA 患者在 ST 和 DT 条件下的平衡能力进行检测。在 DT 条件下，参与者同时进行了步调听觉连续加法测试 (PASAT)。DTC 计算为 ST 与 DT 的相对比率，并控制 ST 的表现：DTC= (ST - DT)/ST x100：结果：在 ST 和 DT 条件下，HA 组的表现明显优于 HD 组（P 结论：在 ST 和 DT 条件下，HA 组的表现明显优于 HD 组）：我们的研究结果表明，增加一项认知任务会干扰受试者的平衡能力，这反映了现实生活中的表现，对于估计向显性疾病的过渡、评估跌倒风险或作为 HD 观察性和干预性试验的有效结果测量，可能具有额外的价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.