Characteristics of immune cells and causal relationship with chondromalacia: A two-sample, bidirectional mendelian randomization study.

IF 2.8 3区 医学 Q2 NEUROSCIENCES
Weiwei Chai, Mengwei Zhang, Yan He, Weihao Chai
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引用次数: 0

Abstract

Chondromalacia, characterized by the softening of cartilage, is a prevalent condition affecting joint health with complex etiology. The immune system's role in its pathogenesis has been implicated but remains to be fully elucidated. To address a critical knowledge gap, we conducted a two-sample Mendelian randomization analysis of 731 immune cell phenotypes, assessing parameters like fluorescence, cell count, and morphology. After sensitivity and pleiotropy checks, and applying a false discovery rate correction, our study linked 17 phenotypes to chondromalacia (p < .05). Among them, seven immune cell phenotypes were found to have a protective effect against chondromalacia (IVW: p < .05, OR <1), while 10 were considered risk factors (IVW:p < .05, OR >1). Despite the constraints of sample size and possible genetic differences among populations, our research has identified a notable genetic correlation between specific immune cell indicators and chondromalacia. This breakthrough sheds light on the pathophysiological mechanisms of the condition. The identification of protective and risk-associated immune cell phenotypes provides a foundation for further exploration of immunological mechanisms in chondromalacia and may pave the way for targeted interventions. Future research is warranted to validate these findings and explore their clinical implications.

免疫细胞的特征及与软骨软化症的因果关系:双样本、双向孟德尔随机研究
软骨软化症以软骨软化为特征,是一种影响关节健康的常见疾病,病因复杂。免疫系统在其发病机制中的作用已被提及,但仍有待全面阐明。为了填补这一重要的知识空白,我们对 731 种免疫细胞表型进行了双样本孟德尔随机分析,评估了荧光、细胞数量和形态等参数。经过敏感性和多义性检查,并应用错误发现率校正,我们的研究发现 17 种表型与软骨软化症有关(P < 0.05)。其中,7种免疫细胞表型对软骨软化症具有保护作用(IVW:P<0.05,OR<1),10种表型被认为是风险因素(IVW:P<0.05,OR>1)。尽管受到样本量和人群间可能存在遗传差异的限制,我们的研究还是发现了特定免疫细胞指标与软骨软化症之间存在显著的遗传相关性。这一突破揭示了软骨软化症的病理生理机制。保护性免疫细胞表型和风险相关免疫细胞表型的确定为进一步探索软骨软化症的免疫机制奠定了基础,并可能为有针对性的干预措施铺平道路。未来的研究需要验证这些发现并探索其临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molecular Pain
Molecular Pain 医学-神经科学
CiteScore
5.60
自引率
3.00%
发文量
56
审稿时长
6-12 weeks
期刊介绍: Molecular Pain is a peer-reviewed, open access journal that considers manuscripts in pain research at the cellular, subcellular and molecular levels. Molecular Pain provides a forum for molecular pain scientists to communicate their research findings in a targeted manner to others in this important and growing field.
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