Intelligent Ureteral Stent Placeable via Standard Procedure for Kidney Pressure Telemetry: An Ex-Vivo Study.

IF 3 2区 医学 Q3 ENGINEERING, BIOMEDICAL
Mohammad Reza Yousefi Darestani, Dirk Lange, Ben H Chew, Kenichi Takahata
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引用次数: 0

Abstract

This paper reports the first telemetric ureteral stent compatible with common placement procedure, enabling wireless sensing and detection of ureteral obstruction and resultant kidney swelling known as hydronephrosis at an early stage. This sensor-integrated "intelligent" ureteral stent is prototyped via the design and fabrication approaches that raise the practicality of the device and tested in a harvested swine kidney-ureter model ex vivo. Leveraging a polymeric double-J stent and micro-electro-mechanical systems technology, the intelligent stent is built by embedding micro pressure sensors and a radiofrequency antenna, forming a resonant circuit that enables wireless kidney pressure monitoring in an operating frequency of 40-50 MHz. The stent device is entirely packaged with Parylene-C for both biocompatibility and electrical insulation of the device in order to function in the real environment including urine, an electrically conductive liquid. A comparison between the results measured in in-vitro and ex-vivo settings show a good match in the sensitivity to applied pressure. In particular, the ex-vivo test in the kidney-ureter model pressurized with artificial urine in a cycled manner demonstrates wireless pressure tracking with a response of 1.3 kHz/mmHg, over pressures up to 37 mmHg that well covers a range of pressure increase known for chronic obstruction. This testing is enabled by the prototype placement into the ex-vivo model using the standard stenting technique and tools without noticeable functional degradation or failures, showing potential compatibility of the device with today's clinical need as a ureteral stent.

可通过标准程序放置的智能输尿管支架用于肾压遥测:体外研究
本文报道了首个与普通置放程序兼容的遥测输尿管支架,可在早期无线感应和检测输尿管梗阻及由此导致的肾肿胀(即肾积水)。这种集成传感器的 "智能 "输尿管支架通过设计和制造方法制成原型,提高了设备的实用性,并在收获的猪肾-输尿管模型中进行了体外测试。利用聚合物双 J 支架和微机电系统技术,该智能支架通过嵌入微型压力传感器和射频天线,形成一个谐振电路,实现了工作频率为 40-50 MHz 的无线肾脏压力监测。该支架装置完全采用聚对苯二甲酸乙二醇(Parylene-C)包装,具有生物兼容性和电气绝缘性,可在包括尿液(一种导电液体)在内的实际环境中发挥作用。对体外和体内测量结果的比较显示,两者对外加压力的敏感性非常吻合。特别是,在肾脏输尿管模型中以循环方式对人造尿液加压进行的体外测试表明,在高达 37 mmHg 的压力下,无线压力跟踪的响应为 1.3 kHz/mmHg,很好地涵盖了已知慢性梗阻的压力增加范围。通过使用标准支架技术和工具将原型放入体外模型进行测试,没有发现明显的功能退化或故障,这表明该装置作为输尿管支架与当今临床需求的潜在兼容性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Biomedical Engineering
Annals of Biomedical Engineering 工程技术-工程:生物医学
CiteScore
7.50
自引率
15.80%
发文量
212
审稿时长
3 months
期刊介绍: Annals of Biomedical Engineering is an official journal of the Biomedical Engineering Society, publishing original articles in the major fields of bioengineering and biomedical engineering. The Annals is an interdisciplinary and international journal with the aim to highlight integrated approaches to the solutions of biological and biomedical problems.
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