Histological Changes in Skin and Subcutaneous Cellular Tissue in Patients with Massive Weight Loss After Bariatric Surgery.

IF 2 3区医学 Q2 SURGERY

Aesthetic Plastic Surgery Pub Date : 2024-09-23 DOI:10.1007/s00266-024-04376-5

Miguel Cálix, Rodrigo Menéndez, Mauricio Baley, Alberto Cadena, Claudia Carrillo, Jafet García-Jiménez

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引用次数: 0

Abstract

Introduction: Morbid obesity is a public health problem with high social and economic impact. Due to failure in its treatment with traditional weight loss strategies, surgical interventions are usually required, which give rise to massive weight loss. Until now, the studies made are inconclusive regarding the histological changes in the skin caused by massive weight loss, which may later generate post-surgical complications. Therefore, the objective of this study is to evaluate the cutaneous histological changes before and after bariatric surgery.

Material and methods: Two skin biopsies were taken from nine different patients who underwent bariatric surgery. The first biopsy was taken before the surgical intervention, and the second biopsy was taken a year after the surgery and massive weight loss. Histological analysis was performed using haematoxylin & eosin staining, Weigert's Resorcin-Fuchsin, and Masson's trichrome stain to analyse the percentage of collagen fibres, percentage of fibrosis, percentage of vascularity, vascular layer involvement and adipocyte population. The differences between the biopsies were evaluated with the Student's T test and Mann-Whitney U test, with a p-value of <0.05.

Results: Biopsies from post-bariatric patients with MWL showed an increase in fibrosis percentage, and a decrease in collagen fibres, elastic fibres of the dermis, adipocyte population, as well as reduced vascular proliferation.

Conclusion: MWL after bariatric surgery gives rise to changes in the skin and subcutaneous cellular tissue. Skin shows an increased fibrosis percentage after massive weight loss. Elastic and collagen fibres become disorganized after massive weight loss. Vascular proliferation is decreased after massive weight loss.

Level of evidence iv: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

查看原文本刊更多论文

减肥手术后体重大幅下降患者皮肤和皮下细胞组织的组织学变化。

引言病态肥胖是一个公共卫生问题，对社会和经济影响很大。由于传统的减肥策略未能奏效，通常需要进行手术干预，从而导致体重大幅下降。迄今为止，有关大量减肥引起的皮肤组织学变化的研究尚无定论，这些变化可能会在手术后产生并发症。因此，本研究旨在评估减肥手术前后的皮肤组织学变化：从九名接受减肥手术的患者身上采集了两份皮肤活检样本。第一次活检在手术前进行，第二次活检在手术和体重大幅下降一年后进行。组织学分析采用了血红素和伊红染色法、魏格特瑞辛-福辛染色法和马森三色染色法，以分析胶原纤维的百分比、纤维化的百分比、血管的百分比、血管层受累情况和脂肪细胞数量。用学生 T 检验和曼-惠特尼 U 检验评估活检样本之间的差异，P 值为结果：减肥术后 MWL 患者的活检结果显示，纤维化百分比增加，胶原纤维、真皮弹性纤维和脂肪细胞数量减少，血管增生减少：结论：减肥手术后的 MWL 会引起皮肤和皮下细胞组织的变化。大量减肥后，皮肤纤维化比例增加。大量减肥后，弹性纤维和胶原纤维变得杂乱无章。大量减肥后血管增生减少。证据级别iv：本期刊要求作者为每篇文章指定一个证据级别。有关这些循证医学等级的完整描述，请参阅目录或在线作者须知 www.springer.com/00266 。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aesthetic Plastic Surgery 医学-外科

CiteScore

4.40

自引率

25.00%

发文量

479

审稿时长

3 months

期刊介绍： Aesthetic Plastic Surgery is a publication of the International Society of Aesthetic Plastic Surgery and the official journal of the European Association of Societies of Aesthetic Plastic Surgery (EASAPS), Società Italiana di Chirurgia Plastica Ricostruttiva ed Estetica (SICPRE), Vereinigung der Deutschen Aesthetisch Plastischen Chirurgen (VDAPC), the Romanian Aesthetic Surgery Society (RASS), Asociación Española de Cirugía Estética Plástica (AECEP), La Sociedad Argentina de Cirugía Plástica, Estética y Reparadora (SACPER), the Rhinoplasty Society of Europe (RSE), the Iranian Society of Plastic and Aesthetic Surgeons (ISPAS), the Singapore Association of Plastic Surgeons (SAPS), the Australasian Society of Aesthetic Plastic Surgeons (ASAPS), the Egyptian Society of Plastic and Reconstructive Surgeons (ESPRS), and the Sociedad Chilena de Cirugía Plástica, Reconstructiva y Estética (SCCP). Aesthetic Plastic Surgery provides a forum for original articles advancing the art of aesthetic plastic surgery. Many describe surgical craftsmanship; others deal with complications in surgical procedures and methods by which to treat or avoid them. Coverage includes "second thoughts" on established techniques, which might be abandoned, modified, or improved. Also included are case histories; improvements in surgical instruments, pharmaceuticals, and operating room equipment; and discussions of problems such as the role of psychosocial factors in the doctor-patient and the patient-public interrelationships. Aesthetic Plastic Surgery is covered in Current Contents/Clinical Medicine, SciSearch, Research Alert, Index Medicus-Medline, and Excerpta Medica/Embase.